Predicting Survival After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Appendix Adenocarcinoma

Diseases of the Colon and Rectum
Omer AzizSarah T O'Dwyer

Abstract

Appendix adenocarcinomas are rare tumors with propensity for peritoneal metastasis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is an established treatment with curative intent, but, to date, studies reporting survival have been heterogeneous with regard to their patient groups (including other tumor types), interventions (not all patients receiving intraperitoneal chemotherapy), and follow-up (varying surveillance protocols). The aim of this study is to quantify the impact of this intervention on survival in a homogeneous group of patients with appendix adenocarcinoma receiving standardized treatment and follow-up, and to determine the impact of prognostic indicators on survival. This is a retrospective analysis of a prospective database at a national peritoneal tumor center where all patients had their appendix pathology reviewed and management planned by a specialized peritoneal tumor multidisciplinary team. Data were extracted on prognostic indicators including peritoneal cancer index, completeness of cytoreduction score, preoperative tumor markers, and histological features. Overall and disease event-free survival from the date of intervention were evaluated using Kaplan Meier curves and univariate...Continue Reading

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Citations

Jan 6, 2019·Abdominal Radiology·David J BartlettShannon P Sheedy
Aug 19, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mackenzie C MorrisSameer H Patel
Jul 24, 2020·World Journal of Surgical Oncology·Jie JiaoPeiming Guo
May 10, 2020·Journal of Surgical Oncology·J C ChenJordan M Cloyd
Jun 20, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R FishS T O'Dwyer
Aug 23, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Andreas LarentzakisMalcolm Wilson
Mar 27, 2021·American Society of Clinical Oncology Educational Book·Richard S HoehnNathan Bahary
Oct 8, 2020·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Michael FloodAlexander Heriot
Nov 30, 2021·Journal of Surgical Oncology·Christopher W MangieriEdward A Levine

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