Predicting survival among high-risk pediatric cardiac transplant recipients: an analysis of the United Network for Organ Sharing database

The Journal of Thoracic and Cardiovascular Surgery
Ryan R DaviesJonathan M Chen

Abstract

Studies of high-risk pediatric cardiac transplant recipients are lacking. The purpose of this study is to evaluate early posttransplant survival in high-risk pediatric patients. The United Network for Organ Sharing (UNOS) provided de-identified patient-level data. The study population included 3502 recipients aged less than 21 years who underwent transplantation from January 1, 1995, through December 31, 2005. Recipients were stratified on the basis of the presence or absence of high-risk criteria: pulmonary vascular resistance index greater than 6 Wood units/m2 (n = 285, 8.1%), creatinine clearance less than 40 mL/min (308, 8.8%), hepatitis C positivity (33, 0.9%), donor/recipient weight ratio less than 0.7 (80, 2.3%), panel reactive antibody greater than 40% (235, 6.7%), retransplantation (235, 6.7%), and age less than 1 year old (840, 24.0%). Overall, 1575 (45.0%) patients met at least one high-risk criterion. Higher numbers of high-risk criteria in a patient were correlated with increased 30-day mortality (0 high-risk criteria: 5.2%; 1 criterion: 7.9%; 2 criteria: 12.9%; and 3 or more criteria: 25.0%; P < .0001) and poor long-term survival (P < .0001). Among patients with high-risk criteria, a simplified scoring scale accur...Continue Reading

References

Jan 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Hillel LaksUNKNOWN UCLA Heart Tranplant Group
Dec 12, 2003·The Annals of Thoracic Surgery·Jeffrey A MorganNiloo M Edwards
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Gregory D TrachiotisKirk R Kanter
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jennifer HuangCharles E Canter
Oct 7, 2004·The Annals of Thoracic Surgery·Jonathan M ChenRalph S Mosca
Dec 29, 2004·The Annals of Thoracic Surgery·Jan GroetznerSabine Daebritz
Jun 25, 2005·The Annals of Thoracic Surgery·Jonathan M ChenYoshifumi Naka
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G Michael FelkerStuart D Russell
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jan GroetznerBruno Reichart
May 23, 2006·Pediatric Transplantation·Shobha Sahney, Richard Chinnock
Oct 19, 2006·JAMA : the Journal of the American Medical Association·Leanne B GasinkEbbing Lautenbach
Oct 26, 2006·The Annals of Thoracic Surgery·Stefan KlotzHans H Scheld
Dec 21, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeffrey J KimWilliam J Dreyer
Jan 24, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Stacey M Pollock BarZivAnne I Dipchand

❮ Previous
Next ❯

Citations

Sep 6, 2011·Pediatric Cardiology·Scott R AuerbachJacqueline M Lamour
Jun 28, 2014·The Annals of Thoracic Surgery·Ryan R DaviesChristian Pizarro
Apr 15, 2014·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Anees J Razzouk, Leonard L Bailey
Jul 28, 2013·The Journal of Thoracic and Cardiovascular Surgery·Minoo N KavaranaScott M Bradley
Apr 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·Ryan R DaviesJan M Quaegebeur
Feb 14, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Melanie D EverittUNKNOWN Pediatric Heart Transplant Study Investigators
Dec 16, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joshua R KovachSteven D Zangwill
Jan 19, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraUNKNOWN International Society for Heart Lung Transplantation (ISHLT) Heart Failure and Transplantation Council
Oct 25, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Peter ChiuJonathan M Chen
Jun 17, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mackenzie A FordTajinder P Singh
Jan 19, 2011·The Journal of Thoracic and Cardiovascular Surgery·Rupali GandhiRavi R Thiagarajan
Jan 17, 2012·Pediatric Transplantation·Gail StendahlSteven Zangwill
May 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R DaviesC Pizarro
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C S AlmondT P Singh
Jun 19, 2013·Pediatric Transplantation·Yamuna Sanil, Sanjeev Aggarwal
Jul 28, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryan R DaviesChristian Pizarro
Apr 9, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryan R DaviesChristian Pizarro
Jun 8, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc E RichmondUNKNOWN Pediatric Heart Transplant Study Investigators
Sep 13, 2015·JACC. Heart Failure·Scott R Auerbach
Feb 5, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J MathewA Lorts
Jun 28, 2013·World Journal for Pediatric & Congenital Heart Surgery·Ryan R Davies, Christian Pizarro
Oct 3, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kyle W RiggsDavid L S Morales
Oct 1, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Getanshu MalikJennifer Conway
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Getanshu MalikJennifer Conway
Jan 31, 2019·Pediatric Transplantation·Rebecca MillerJoseph D Tobias
Sep 6, 2020·Pediatric Clinics of North America·Adam Putschoegl, Scott Auerbach
Apr 24, 2018·The Annals of Thoracic Surgery·Matthew J O'ConnorKimberly Y Lin
May 1, 2021·Journal of Clinical Medicine·Priya BhaskarRavi Thiagarajan
Jul 14, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J B EdelsonJ W Rossano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Yanto Sandy TjangReiner Körfer
The Journal of Thoracic and Cardiovascular Surgery
David L S MoralesCharles D Fraser
Journal of the American College of Cardiology
K Anitha JayakumarDaphne T Hsu
Pediatric Cardiology
N S GhanayemJ S Tweddell
© 2021 Meta ULC. All rights reserved