Predicting Survival of Congenital Diaphragmatic Hernia on the First Day of Life

World Journal of Surgery
Chaeyoun OhSung-Eun Jung

Abstract

This study aimed to determine perinatal risk factors for 30-day mortality of congenital diaphragmatic hernia (CDH) patients and develop a prognostic index to predict 30-day mortality of CDH patients. Identifying risk factors that can prognosticate outcome is critical to obtain the best management practices for patients. A retrospective study was performed for patients who were diagnosed with CDH from November 2000 to August 2016. A total of 10 prenatal risk factors and 14 postnatal risk factors were analyzed. All postnatal variables were measured within 24 h after birth. A total of 95 CDH patients were enrolled in this study, including 61 males and 34 females with mean gestational age of 38.86 ± 1.51 weeks. The overall 30-day survival rate was 63.2%. Multivariate analysis revealed that five factors (polyhydramnios, gestational age at diagnosis <25 weeks, observed-to-expected lung-to-head ratio ≤45, best oxygenation index in 24 h  >11, and severity of tricuspid regurgitation ≥ mild) were independent predictors of 30-day mortality of CDH. Using these five factors, a perinatal prognostic index for 30-day mortality was developed. Four predictive models (poor, bad, good, and excellent) of the perinatal prognostic index were construc...Continue Reading

References

Jan 1, 1992·American Journal of Obstetrics and Gynecology·G K SharlandL D Allan
Jul 1, 1989·Journal of Pediatric Surgery·N S AdzickJ M Wilson
Jun 1, 1989·British Journal of Obstetrics and Gynaecology·D C CrawfordL D Allan
Jun 1, 1994·Journal of Pediatric Surgery·J M WilsonW H Hendren
Jan 1, 1994·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·S A ReisnerR Beyar
Jan 1, 1996·Journal of Pediatric Surgery·A P MetkusN S Adzick
Dec 17, 1998·Prenatal Diagnosis·C T AlbaneseM R Harrison
Nov 7, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F BahlmannM Hofmann
Sep 6, 2000·Pediatric Pulmonology·M W Beresford, N J Shaw
Jan 11, 2001·Journal of Pediatric Surgery·UNKNOWN Congenital Diaphragmatic Hernia Study Group
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Desmond Bohn
Apr 30, 2003·Journal of Pediatric Surgery·Cynthia D DownardJay M Wilson
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
May 12, 2004·Journal of Pediatric Surgery·Patrick J JavidUNKNOWN Canadian Neonatal Network
Feb 11, 2005·Pediatric Pulmonology·Daniel TrachselAllan L Coates
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·Daniel TrachselDesmond Bohn
Jul 30, 2005·Seminars in Perinatology·Robbert Rottier, Dick Tibboel
Dec 24, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J JaniUNKNOWN Antenatal-CDH-Registry Group
Jan 19, 2006·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·S FuminoN Iwai
Apr 6, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J JaniK H Nicolaides
Mar 6, 2007·Journal of Pediatric Surgery·Cynthia M SchultzUNKNOWN Congenital Diaphragmatic Hernia Study Group
Jun 26, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J JaniUNKNOWN Antenatal-CDH-Registry Group
Feb 24, 2009·Journal of Pediatric Surgery·Chandrasen K SinhaMark Davenport
May 3, 2011·American Journal of Obstetrics and Gynecology·Malikah A AlfarajGreg Ryan
Sep 8, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R RuanoM Zugaib
Sep 29, 2011·American Journal of Obstetrics and Gynecology·Rubén A QuinteroEftichia V Kontopoulos
Oct 11, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rubén A QuinteroRamen H Chmait
Feb 5, 2013·The Journal of Pediatrics·Julia WynnMarc S Arkovitz
Feb 28, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Rodrigo RuanoMarcelo Zugaib
Jul 16, 2014·Pediatrics·Mary Elizabeth BrindleUNKNOWN Congenital Diaphragmatic Hernia Study Group
Dec 3, 2014·Seminars in Pediatric Surgery·Paul D Losty
Jan 7, 2015·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Elke RuttenstockMark Davenport
Jun 14, 2015·American Journal of Obstetrics and Gynecology·Hanane BouchghoulUNKNOWN Center for Rare Diseases for Congenital Diaphragmatic Hernia
Jan 1, 2015·Maternal Health, Neonatology and Perinatology·Vinay SharmaSatyan Lakshminrusimha

❮ Previous
Next ❯

Citations

Jun 5, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Suzan C M Cochius-den Otter, Dick Tibboel
Mar 7, 2020·Pediatrics·Suzan C M Cochius-den OtterDick Tibboel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.