Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD).

Translational Psychiatry
Paola ColucciPatrizia Campolongo

Abstract

Post-traumatic stress disorder (PTSD) is a psychiatric disorder whose pathogenesis relies on a maladaptive expression of the memory for a life-threatening experience, characterized by over-consolidation, generalization, and impaired extinction, which are responsible of dramatic changes in arousal, mood, anxiety, and social behavior. Even if subjects experiencing a traumatic event during lifetime all show an acute response to the trauma, only a subset of them (susceptible) ultimately develops PTSD, meanwhile the others (resilient) fully recover after the first acute response. However, the dynamic relationships between the interacting brain circuits that might potentially link trauma-related experiences to the emergence of susceptible and resilient PTSD phenotypes in individuals is not well understood. Toward the first step to reach this goal, we have implemented our experimental PTSD model previously developed, making it suitable to differentiate between susceptible (high responders, HR) and resilient (low responders, LR) rats in terms of over-consolidation, impaired extinction, and social impairment long after trauma. Rats were exposed to five footshocks paired with social isolation. One week after trauma but before extinction,...Continue Reading

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Citations

Dec 29, 2020·Behavioural Brain Research·Giulia Federica ManciniPatrizia Campolongo
May 27, 2021·Neurobiology of Stress·Sarah T GonzalezMichael S Fanselow
Jul 12, 2021·Translational Psychiatry·Gal Richter-Levin, Carmen Sandi

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