Predicting the behavior of novel sugar carriers for dry powder inhaler formulations via the use of a cohesive-adhesive force balance approach

Journal of Pharmaceutical Sciences
Jennifer C HootonRobert Price

Abstract

The aim of this work was to utilize the recently developed cohesive-adhesive balance (CAB) technique for analyzing quantitative AFM measurements to compare the relative forces of interaction of micronized salbutamol sulfate particles and a selection of specifically grown sugar substrates (beta cyclodextrin, lactose, raffinose, trehalose and xylitol). The interfacial behavior was subsequently related to the in-vitro delivery performance of these sugars as carrier particles in dry powder inhalation (DPI) formulations. The CAB analysis indicated that the rank order of adhesion between salbutamol sulfate and the sugars was beta cyclodextrin < lactose < trehalose < raffinose < xylitol. The beta cyclodextrin was the only substrate with which salbutamol sulfate demonstrated a greater cohesive behavior. All other sugars exhibited an adhesive dominance. In-vitro deposition performance of the salbutamol sulfate based carrier DPI formulations showed that the rank order of the fine particle fraction (FPF) was beta cyclodextrin > lactose > raffinose > trehalose > xylitol. A linear correlation (R(2) = 0.9572) was observed between the FPF and cohesive-adhesive ratios of the AFM force measurements. The observed link between CAB analysis of the...Continue Reading

References

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Citations

Jul 25, 2012·Therapeutic Delivery·Martin J DonovanHugh D C Smyth
May 29, 2008·Journal of Pharmaceutical Sciences·Darragh MurnaneChristopher Marriott
Dec 11, 2008·Journal of Pharmaceutical Sciences·Philippe BegatRobert Price
Apr 25, 2007·Journal of Pharmaceutical Sciences·Anthony J HickeyDimitris Papadopoulos
Apr 25, 2007·Journal of Pharmaceutical Sciences·Anthony J HickeyDimitris Papadopoulos
Aug 28, 2007·Journal of Pharmaceutical Sciences·Farahidah Mohamed, Christopher F van der Walle
Mar 17, 2010·Journal of Pharmaceutical Sciences·Zhen XuAnthony J Hickey
May 15, 2012·International Journal of Pharmaceutics·Marcin OdziomekLeon Gradoń
Nov 30, 2011·Advanced Drug Delivery Reviews·Xiang KouPaul W S Heng
Nov 29, 2011·Advanced Drug Delivery Reviews·Jagdeep Shur, Robert Price
Aug 26, 2009·International Journal of Pharmaceutics·Satomi OnoueShizuo Yamada
Oct 13, 2015·International Journal of Pharmaceutics·Zihua WangJerry Y Y Heng
Jan 15, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Matthew D JonesRobert Price
Aug 26, 2015·International Journal of Pharmaceutics·Cordula WeissHelen Cathcart
Feb 14, 2015·The Journal of Pharmacy and Pharmacology·Martyn David Ticehurst, Ivan Marziano
Nov 26, 2013·Drug Discovery Today·Yahya RahimpourHamed Hamishehkar
Mar 10, 2017·Drug Development and Industrial Pharmacy·Vahid RamezaniHamed Fanaei
Jun 3, 2017·Drug Development and Industrial Pharmacy·Saurabh SarkarBodhisattwa Chaudhuri
Nov 8, 2014·Molecular Pharmaceutics·Vasuki RamachandranKlimentina Pencheva
Jan 9, 2022·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Dorrin Mohtadi HaghighiAlireza Vatanara

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