Predicting the clinical behavior of ovarian cancer from gene expression profiles

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Frank De SmetIgnace Vergote

Abstract

We investigated whether prognostic information is reflected in the expression patterns of ovarian carcinoma samples. RNA obtained from seven FIGO stage I without recurrence, seven platin-sensitive advanced-stage (III or IV), and six platin-resistant advanced-stage ovarian tumors was hybridized on a complementary DNA microarray with 21,372 spotted clones. The results revealed that a considerable number of genes exhibit nonaccidental differential expression between the different tumor classes. Principal component analysis reflected the differences between the three tumor classes and their order of transition. Using a leave-one-out approach together with least squares support vector machines, we obtained an estimated classification test accuracy of 100% for the distinction between stage I and advanced-stage disease and 76.92% for the distinction between platin-resistant versus platin-sensitive disease in FIGO stage III/IV. These results indicate that gene expression patterns could be useful in clinical management of ovarian cancer.

References

Mar 11, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MarkmanJ L Lewis
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·J B WelshG M Hampton
Jun 5, 2001·Nature Reviews. Genetics·J Quackenbush
Jun 21, 2002·BioTechniques·László G PuskásPaul Van Hummelen
Jul 4, 2002·Journal of the National Cancer Institute·Amir A JazaeriEdison T Liu
Nov 9, 2002·Bioinformatics·Olga G TroyanskayaRuss B Altman
Jan 2, 2003·Journal of the National Cancer Institute·Richard SimonLisa M McShane
Jan 17, 2003·Journal of the National Cancer Institute·J Baptist TrimbosUNKNOWN EORTC-ACTION collaborators. European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neop
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Jan 7, 2004·Journal of the Society for Gynecologic Investigation·Johnathan M LancasterAndrew Berchuck
May 1, 2004·American Journal of Obstetrics and Gynecology·Andrew BerchuckJeffrey R Marks
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen H LuRobert C Bast

❮ Previous
Next ❯

Citations

Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T Van GorpF Amant
Feb 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J DietlJ Wischhusen
Aug 10, 2007·Expert Opinion on Investigational Drugs·Daniela Matei
Apr 18, 2015·BMC Cancer·Katherine L LloydRichard S Savage
Oct 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John D MinnaYang Xie
Jul 25, 2009·Obstetrical & Gynecological Survey·Vanessa N HarryDavid E Parkin
Nov 2, 2018·Scientific Reports·Srinivasulu Yerukala Sathipati, Shinn-Ying Ho
Apr 29, 2021·Aging·Srinivasulu Yerukala Sathipati, Shinn-Ying Ho
Jan 24, 2008·Molecular Cancer·Alexandros LaiosJohn J O' Leary

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Lynn HartmannAndrew I Damokosh
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Dimitrios SpentzosStephen A Cannistra
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
A BerchuckJeffrey R Marks
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Dimitrios SpentzosStephen A Cannistra
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Richard W TothillDavid D L Bowtell
© 2021 Meta ULC. All rights reserved