Abstract
Helicobacter pylori (HP) and gastric atrophy are risk factors for gastric cancer. We evaluated whether the combination of serum HP antibody and pepsinogen (PG), which is indicative of gastric atrophy, could serve as a predictive marker for the development of gastric neoplasms in a Korean population. The subjects who had undergone health-screening examination with endoscopic follow-ups were classified into the following 4 groups according to serum PG status and HP antibody at baseline: group A (HP (-), normal PG), group B (HP (+), normal PG), group C (HP (+), atrophic PG), and group D (HP (-), atrophic PG). We compared the development of gastric neoplasms among the groups. Of the 3297 subjects, 1239 (37.6%) were categorized as group A, 1484 (45.0%) as group B, 536 (16.3%) as group C, and 38 (1.2%) as group D. During the 5.6 years of mean follow-up period, the annual incidence of gastric neoplasms increased gradually by 0.06% in group A, 0.16% in group B, 0.38% in group C, and 0.49% in group D. A Cox proportional hazard model showed increased development of gastric neoplasms according to group (P for trend = 0.025). Compared to group A, the hazard ratio was 8.25 for group D (95% confidence interval 0.2-74.24), 5.35 for group C (1...Continue Reading
References
Jan 1, 1995·Advances in Experimental Medicine and Biology·K MikiK Kurokawa
Apr 16, 1999·Gut·F KitaharaM A Fujino
Jul 18, 2000·Gut·R J SchlemperH Yamabe
Aug 21, 2001·Gut·Y YamajiM Omata
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Jan 22, 2004·International Journal of Cancer. Journal International Du Cancer·Hiroshi OhataMasao Ichinose
Aug 31, 2004·Journal of Medical Screening·M Dinis-RibeiroM Kurihara
May 12, 2005·Gastroenterology·Irvin M ModlinMichael D Shapiro
May 13, 2005·Gut·H WatabeM Omata
Aug 3, 2007·Helicobacter·Jeong Yoon YimByung Hee Oh
Aug 8, 2007·Gastroenterology·Pelayo Correa, Jeanmarie Houghton
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jul 26, 2011·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Kazumasa Miki
Aug 24, 2011·Journal of Neurogastroenterology and Motility·Su Jin ChungIn Sung Song
Nov 9, 2011·Helicobacter·Taiji MatsuoKazuaki Chayama
Jul 4, 2012·International Journal of Cancer. Journal International Du Cancer·Freddie BrayJacques Ferlay
Sep 4, 2012·Journal of Gastrointestinal Oncology·Bing HuAurelia Meloni-Ehrig
Nov 13, 2013·Helicobacter·Tomoyuki BodaKazuaki Chayama
Mar 8, 2014·Journal of Digestive Diseases·Hong Seok ChoiChoon Jo Jin
Oct 15, 2014·PloS One·Teruhiko TerasawaChisato Hamashima
Jul 30, 2015·International Journal of Cancer. Journal International Du Cancer·Hadrien CharvatUNKNOWN JPHC Study Group
Jun 7, 2016·Journal of Epidemiology·Fumie IkedaToshiharu Ninomiya
Jun 23, 2016·Digestion·Ko MiuraHiroyuki Yanai
Dec 3, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eunjung LeeDennis Deapen
Apr 25, 2017·Scandinavian Journal of Gastroenterology·Xiaoteng WangMeng Li