Predicting the dose absorbed by organs at risk during intensity modulated radiation therapy for nasopharyngeal carcinoma

The British Journal of Radiology
Haowen PangJingbo Wu

Abstract

To develop a model for predicting the dose absorbed by organ at risk (OAR) during intensity modulated radiation therapy for nasopharyngeal carcinoma (NPC). 55 patients underwent intensity modulated radiation therapy for NPC. The OARs were divided into several suborgans, and SPSS software was used to evaluate multiple linear method for fitting the normalized volume for each suborgan, normalized mean dose (Dmean) Dnm (Dnm = Dmean/Dprescription), and normalized D10%-D100% values Dn10%-n100%(Dn10%-n100% = D10%-D100%/Dprescription) for each OAR. Based on the Matlab software, the predicted Dn10%-n100% value was fitted to obtain the predicted DVH curve. The multiple linear fitting formulas revealed significant results for the oral cavity Dn100% (p = 0.017), the parotid gland Dn100% (p = 0.001), and the remaining OAR (all p < 0.0001). The correlation coefficients and p values indicated that the fitting formula was a good fit. The p values for the White test show that the prediction model is robust. This method was successfully used for verification cases. The present study provided a simple and effective model for predicting the dose absorbed by OAR for NPC. This method is a relatively simple mathematical model, just use prescription d...Continue Reading

References

Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·J C RoeskeA J Mundt
Aug 15, 2006·International Journal of Radiation Oncology, Biology, Physics·Margie A HuntNancy Lee
Mar 11, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W M LeeTsz Kok Yau
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Shaojun LinJiade J Lu
Jul 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy LeeK Kian Ang
Aug 4, 2009·International Journal of Radiation Oncology, Biology, Physics·Frank C S WongStewart Y Tung
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Kevin L MooreSasa Mutic
Feb 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Jim P TolWilko F A R Verbakel
Jul 19, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mohammad HusseinAndrew Nisbet
Feb 17, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Binbin WuDalong Pang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.