Get paper from

journal cover

Predicting the effects of amino acid substitutions on protein function

Annual Review of Genomics and Human Genetics

Jan 1, 2006

Pauline C Ng, Steven Henikoff

Get paper from

Abstract

Nonsynonymous single nucleotide polymorphisms (nsSNPs) are coding variants that introduce amino acid changes in their corresponding proteins. Because nsSNPs can affect protein function, they are believed to have the largest impact on human health compared with SNPs in other regions of t...read more

Mentioned in this Paper

Amino Acid [EPC]
Amino Acid Substitution
Amino Acid Metabolism, Inborn Errors
Single Nucleotide Polymorphism
Protein Conformation
Protein Function
Atypical Mycobacteriosis, Familial
874
1
Paper Details
References
  • References80
  • Citations382
12345...

Predicting the effects of amino acid substitutions on protein function

Annual Review of Genomics and Human Genetics

Jan 1, 2006

Pauline C Ng, Steven Henikoff

PMID: 16824020

DOI: 10.1146/annurev.genom.7.080505.115630

Abstract

Nonsynonymous single nucleotide polymorphisms (nsSNPs) are coding variants that introduce amino acid changes in their corresponding proteins. Because nsSNPs can affect protein function, they are believed to have the largest impact on human health compared with SNPs in other regions of t...read more

Mentioned in this Paper

Amino Acid [EPC]
Amino Acid Substitution
Amino Acid Metabolism, Inborn Errors
Single Nucleotide Polymorphism
Protein Conformation
874
1
Paper Details
References
  • References80
  • Citations382
12345...

Get paper from

/papers/predicting-the-effects-of-amino-acid/16824020