Predicting the efficacy of surgery for pain relief in patients with alcoholic chronic pancreatitis

Surgery
Benoit BordaçaharVinciane Rebours

Abstract

Recurrent pain is the most disabling complication in patients with chronic pancreatitis. Pancreatic surgery is currently considered as last-resort therapeutic option. The aims of this study were to assess pancreatic surgery performance for chronic pain in patients with alcoholic chronic pancreatitis and to determine factors predictive of therapeutic response. All patients with chronic pancreatitis who underwent pancreatic surgery for chronic pain were included and divided into 2 groups according to the cause of chronic pancreatitis: alcoholic and any other chronic pancreatitis causes as the control group. Alcohol, tobacco, and painkiller intake, quality of life data 6 months and 1 year after surgery, and morphological and pathological features were analyzed. Fifty patients were included in the alcoholic chronic pancreatitis group and 16 patients in the control group. Smoking cessation before pancreatic surgery was achieved in 40% of the alcoholic chronic pancreatitis group compared with 73% of the control group (P = .005). Histological analysis revealed a higher prevalence of hypertrophic nerves and perineural inflammation in the alcoholic chronic pancreatitis group than in the control group (P = .03 and P = .04 respectively). ...Continue Reading

Citations

Jul 18, 2019·Journal of Gastroenterology and Hepatology·Søren S OlesenUNKNOWN Scandinavian Baltic Pancreatic Club
Jan 22, 2019·Expert Review of Clinical Pharmacology·Louise KuhlmannAsbjørn M Drewes
Dec 21, 2019·JAMA : the Journal of the American Medical Association·Vikesh K SinghPramod K Garg
Aug 16, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Asbjørn M DrewesJohn A Windsor

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