Predicting the impact of insecticide-treated bed nets on malaria transmission: the devil is in the detail.

Malaria Journal
Weidong Gu, Robert J Novak

Abstract

Insecticide-treated bed nets (ITNs), including long-lasting insecticidal nets (LLINs), play a primary role in global campaigns to roll back malaria in tropical Africa. Effectiveness of treated nets depends on direct impacts on individual mosquitoes including killing and excite-repellency, which vary considerably among vector species due to variations in host-seeking behaviours. While monitoring and evaluation programmes of ITNs have focuses on morbidity and all-cause mortality in humans, local entomological context receives little attention. Without knowing the dynamics of local vector species and their responses to treated nets, it is difficult to predict clinical outcomes when ITN applications are scaled up across African continent. Sound model frameworks incorporating intricate interactions between mosquitoes and treated nets are needed to develop the predictive capacity for scale-up applications of ITNs. An established agent-based model was extended to incorporate the direct outcomes, e.g. killing and avoidance, of individual mosquitoes exposing to ITNs in a hypothetical village setting with 50 houses and 90 aquatic habitats. Individual mosquitoes were tracked throughout the life cycle across the landscape. Four levels of c...Continue Reading

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Citations

Nov 29, 2012·Environmental Science & Technology·Jonathan E MellorRebecca A Dillingham
Jul 30, 2011·Parasites & Vectors·Michael T WhiteAzra C Ghani
May 26, 2012·PloS One·Guilhem RascalouSébastien Gourbière
Jul 25, 2012·The American Journal of Tropical Medicine and Hygiene·Eskindir Loha, Bernt Lindtjørn
Aug 27, 2014·Journal of Theoretical Biology·Calistus N NgonghalaJemal Mohammed-Awel
Mar 16, 2016·Journal of Theoretical Biology·Calistus N NgonghalaOlivia Prosper
Sep 1, 2015·Evolution, Medicine, and Public Health·Philip L G Birget, Jacob C Koella
Feb 26, 2016·Journal of the Royal Society, Interface·Ezer MillerAmit Huppert
Aug 7, 2010·PLoS Medicine·Heather M FergusonGerry F Killeen
Feb 23, 2017·Malaria Journal·Michael ColemanCatherine L Moyes
Aug 19, 2018·Malaria Journal·Neal R SmithJennifer A Flegg
May 25, 2020·Journal of Mathematical Biology·Iboi EnahoroKrijn Paaijmans

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