Predicting the integration of overlapping memories by decoding mnemonic processing states during learning

NeuroImage
Franziska R RichterBrice A Kuhl

Abstract

The hippocampal memory system is thought to alternate between two opposing processing states: encoding and retrieval. When present experience overlaps with past experience, this creates a potential tradeoff between encoding the present and retrieving the past. This tradeoff may be resolved by memory integration-that is, by forming a mnemonic representation that links present experience with overlapping past experience. Here, we used fMRI decoding analyses to predict when - and establish how - past and present experiences become integrated in memory. In an initial experiment, we alternately instructed subjects to adopt encoding, retrieval or integration states during overlapping learning. We then trained across-subject pattern classifiers to 'read out' the instructed processing states from fMRI activity patterns. We show that an integration state was clearly dissociable from encoding or retrieval states. Moreover, trial-by-trial fluctuations in decoded evidence for an integration state during learning reliably predicted behavioral expressions of successful memory integration. Strikingly, the decoding algorithm also successfully predicted specific instances of spontaneous memory integration in an entirely independent sample of su...Continue Reading

References

Dec 1, 1994·Hippocampus·R C O'Reilly, J L McClelland
Jan 3, 2001·NeuroImage·D I DonaldsonR L Buckner
Feb 25, 2005·Journal of Neurophysiology·Steve KunecNancy Kopell
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura L EldridgeBarbara J Knowlton
Dec 24, 2005·Science·Sean M PolynKenneth A Norman
Apr 7, 2007·Science·Dorothy TseRichard G M Morris
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susan G R McDuffKenneth A Norman
Jun 30, 2009·NeuroImage·Yukiyasu Kamitani, Yasuhito Sawahata
Nov 4, 2009·Psychological Science·Russell A PoldrackStephen José Hanson
Nov 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Markus SiegelEarl K Miller
May 4, 2010·Neuron·Adrián HernándezRanulfo Romo
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jesse RissmanAnthony D Wagner
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dagmar Zeithamova, Alison R Preston
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brice A KuhlAnthony D Wagner
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brice A KuhlMarvin M Chun
Apr 4, 2012·Frontiers in Human Neuroscience·Dagmar ZeithamovaAlison R Preston
Apr 7, 2012·Current Opinion in Neurobiology·Margaret F Carr, Loren M Frank
Jul 11, 2012·Psychological Review·Dharshan Kumaran, James L McClelland
Oct 16, 2012·Science·G Elliott Wimmer, Daphna Shohamy
May 17, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent DouchampsColin Lever
Sep 14, 2013·Current Biology : CB·Alison R Preston, Howard Eichenbaum
Oct 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brice A KuhlMarvin M Chun
Jun 4, 2014·Hippocampus·Margaret L SchlichtingAlison R Preston
Jun 6, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brice A Kuhl, Marvin M Chun
Aug 22, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katherine DuncanLila Davachi
Oct 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Margaret L Schlichting, Alison R Preston
Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Roland G BenoitDaniel L Schacter
Mar 10, 2015·Current Opinion in Behavioral Sciences·Margaret L Schlichting, Alison R Preston

❮ Previous
Next ❯

Citations

Jun 16, 2016·Frontiers in Systems Neuroscience·Marlieke T R van KesterenAnthony D Wagner
Dec 15, 2016·Proceedings of the National Academy of Sciences of the United States of America·Roland G BenoitMichael C Anderson
Feb 24, 2017·Nature Neuroscience·Jonathan D CohenTheodore L Willke
Mar 3, 2017·Journal of Cognitive Neuroscience·Dagmar Zeithamova, Alison R Preston
Jul 7, 2018·Hippocampus·Charan Ranganath
Aug 8, 2018·Scientific Reports·Nicole S RafidiKenneth A Norman
Jan 12, 2019·NPJ Science of Learning·Marlieke Tina Renée van KesterenMartijn Meeter
Oct 23, 2019·Frontiers in Psychology·D Eric Chamberlin
Nov 27, 2019·Nature Communications·Avi J H ChanalesBrice A Kuhl
Mar 18, 2020·Scientific Reports·Marlieke T R van KesterenMartijn Meeter
Dec 6, 2016·Learning & Memory·Lisa C Dandolo, Lars Schwabe
Jun 14, 2018·Cerebral Cortex·Ghootae KimNicholas B Turk-Browne
May 19, 2019·Nature Communications·Roland G BenoitDaniel L Schacter
Nov 17, 2019·Learning & Memory·Carolin SieversLouis Renoult
Jul 14, 2020·NPJ Science of Learning·Marlieke Tina Renée van Kesteren, Martijn Meeter
Nov 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·David StawarczykJeffrey M Zacks
Nov 23, 2020·Neuroscience and Biobehavioral Reviews·Oliver Kliegl, Karl-Heinz T Bäuml
Feb 13, 2021·Current Biology : CB·Nicole M Long, Brice A Kuhl
Feb 14, 2021·NPJ Science of Learning·Marlieke Tina Renée van Kesteren, Martijn Meeter
Dec 31, 2019·Neuropsychologia·Hannah Tarder-StollMariam Aly
May 31, 2021·Brain and Cognition·Lindsay B ConnerNichole R Lighthall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved