Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density

ELife
John BradleyTeun Bousema

Abstract

Understanding the importance of gametocyte density on human-to-mosquito transmission is of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a complex relationship between gametocyte density and mosquito infection. Here we use data from 148 feeding experiments on naturally infected gametocyte carriers to show that the relationship is much simpler and depends on both female and male parasite density. The proportion of mosquitoes infected is primarily determined by the density of female gametocytes though transmission from low gametocyte densities may be impeded by a lack of male parasites. Improved precision of gametocyte quantification simplifies the shape of the relationship with infection increasing rapidly before plateauing at higher densities. The mean number of oocysts per mosquito rises quickly with gametocyte density but continues to increase across densities examined. The work highlights the importance of measuring both female and male gametocyte density when estimating the human reservoir of infection.

References

Dec 30, 1999·Science·R E PaulP T Brey
Feb 19, 2002·Trends in Parasitology·Richard E L PaulVincent Robert
Jul 24, 2003·Journal of Theoretical Biology·A GardnerS A West
May 30, 2008·Nature·Sarah E ReeceAndy Gardner
Mar 23, 2010·Evolutionary Applications·Sarah E ReeceDaniel H Nussey
Jul 3, 2013·PLoS Pathogens·Thierry LefèvreAnna Cohuet
Dec 7, 2013·PloS One·Rahel WampflerIngrid Felger
Jan 28, 2015·The American Journal of Tropical Medicine and Hygiene·Abdoulaye GayeCheikh Sokhna
Dec 17, 2015·The Journal of Infectious Diseases·Jessica T LinDavid L Saunders
Jan 4, 2017·International Journal for Parasitology·Kirakorn KiattibutrJetsumon Sattabongkot
Jan 9, 2018·The Journal of Infectious Diseases·Lisette Meerstein-KesselWill Stone
Feb 10, 2018·Nature Communications·Will J R StoneMatthijs M Jore

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Citations

Nov 15, 2018·PLoS Pathogens·Petra SchneiderSarah E Reece
Feb 13, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John BradleyTeun Bousema
Dec 17, 2019·Immunological Reviews·Roos M de JongTeun Bousema
Oct 5, 2018·Proceedings. Biological Sciences·Petra SchneiderSarah E Reece
Apr 8, 2020·Frontiers in Microbiology·Giulia SicilianoElena A Levashina
Nov 26, 2020·Proceedings. Biological Sciences·J IsaïaR Pigeault
Mar 27, 2021·Scientific Reports·Lauren M CoheeMiriam K Laufer
Sep 13, 2020·Trends in Parasitology·Robert S McCannMiriam K Laufer
May 24, 2021·Molecular and Biochemical Parasitology·Petra Schneider, Sarah E Reece
Dec 15, 2021·Clinical Pharmacology and Therapeutics·Palang ChotsiriJoel Tarning

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Methods Mentioned

BETA
PCR
dissection
transgenic

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