Predicting the naturalistic course in anxiety disorders using clinical and biological markers: a machine learning approach.

Psychological Medicine
Wicher A BokmaGuido A van Wingen

Abstract

Disease trajectories of patients with anxiety disorders are highly diverse and approximately 60% remain chronically ill. The ability to predict disease course in individual patients would enable personalized management of these patients. This study aimed to predict recovery from anxiety disorders within 2 years applying a machine learning approach. In total, 887 patients with anxiety disorders (panic disorder, generalized anxiety disorder, agoraphobia, or social phobia) were selected from a naturalistic cohort study. A wide array of baseline predictors (N = 569) from five domains (clinical, psychological, sociodemographic, biological, lifestyle) were used to predict recovery from anxiety disorders and recovery from all common mental disorders (CMDs: anxiety disorders, major depressive disorder, dysthymia, or alcohol dependency) at 2-year follow-up using random forest classifiers (RFCs). At follow-up, 484 patients (54.6%) had recovered from anxiety disorders. RFCs achieved a cross-validated area-under-the-receiving-operator-characteristic-curve (AUC) of 0.67 when using the combination of all predictor domains (sensitivity: 62.0%, specificity 62.8%) for predicting recovery from anxiety disorders. Classification of recovery from C...Continue Reading

References

Jun 29, 2001·Archives of General Psychiatry·W A VolleberghJ Ormel
Jul 12, 2005·Atherosclerosis·Christos PitsavosChristodoulos Stefanadis
Feb 16, 2006·The Journal of Nervous and Mental Disease·Benjamin F RodriguezMartin B Keller
Jan 4, 2007·BMC Bioinformatics·Gilles DidierIvan Laprevotte
Sep 4, 2008·International Journal of Methods in Psychiatric Research·Brenda W J H PenninxUNKNOWN NESDA Research Consortium
Mar 17, 2010·Brain, Behavior, and Immunity·Aoife O'DonovanKevin M Malone
Apr 14, 2010·Bioinformatics·André AltmannThomas Lengauer
Nov 6, 2010·Psychoneuroendocrinology·Peggy M ZoccolaIlona S Yim
Sep 6, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marc L MolendijkBernet M Elzinga
May 29, 2012·Acta Psychiatrica Scandinavica·K Beesdo-BaumH-U Wittchen
Jun 22, 2012·Psychological Medicine·W E CopelandE J Costello
Oct 31, 2012·Acta Psychiatrica Scandinavica·Sanne M HendriksBrenda W J H Penninx
Dec 12, 2012·Journal of Affective Disorders·Willemijn D ScholtenPatricia van Oppen
Apr 25, 2013·Translational Psychiatry·N VogelzangsB W J H Penninx
May 25, 2013·Clinical Psychology Review·Johan OrmelAlbertine J Oldehinkel
Nov 19, 2013·Behavioural Brain Research·Andreas FrickTomas Furmark
Nov 26, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tali M BallMartin P Paulus
May 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Abdulkader AlbasriAhmed Alhujaily
Jun 10, 2014·The Journal of Clinical Psychiatry·Neeltje M BatelaanBrenda W J H Penninx
Jan 27, 2015·Current Psychiatry Reports·Eva Asselmann, Katja Beesdo-Baum
Aug 12, 2015·Molecular Psychiatry·S Whitfield-GabrieliJ D E Gabrieli
Nov 7, 2015·Journal of Affective Disorders·Johanna Hm Hovenkamp-HermelinkRobert A Schoevers
Nov 18, 2015·Circulation·Rahul C Deo
Feb 21, 2016·Journal of Affective Disorders·Willemijn D ScholtenPatricia van Oppen
Nov 16, 2016·Molecular Psychiatry·T HahnS Whitfield-Gabrieli
Feb 24, 2017·Nature Neuroscience·Choong-Wan WooTor D Wager
Mar 14, 2018·BMC Psychiatry·Kristin GustavsonTed Reichborn-Kjennerud
May 8, 2018·The Journal of Hand Surgery Asian-Pacific Volume·Masanori NakayamaKatsunori Ikari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Dialogues in Clinical Neuroscience
B Bandelow, Sophie Michaelis
The Journal of the American Osteopathic Association
Charles I Shelton
The Journal of the American Osteopathic Association
Charles I Shelton
© 2022 Meta ULC. All rights reserved