Predicting the onset of glaucoma: the confocal scanning laser ophthalmoscopy ancillary study to theOcular Hypertension Treatment Study.

Ophthalmology
Robert N WeinrebOHTS CSLO Ancillary Study Group

Abstract

To evaluate the predictive ability of baseline confocal scanning laser ophthalmoscopy (CSLO) Glaucoma Probability Score (GPS) for the development of primary open-angle glaucoma (POAG) and to compare it with the Moorfields regression analysis (MRA) classification, other topographic optic disc parameters, and stereophotograph-based cup-to-disc ratio. Longitudinal, randomized clinical trial. We included 857 eyes of 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study (OHTS) with good quality baseline CSLO images. The ability of baseline GPS, MRA, and optic disc parameters to predict the development of POAG was evaluated in univariate and multivariable proportional hazard ratio analyses. Likelihood ratios and positive and negative predictive values were compared. The POAG end point as determined by repeatable changes in the visual field or optic disc. Sixty-four eyes of 50 CSLO Ancillary Study participants developed POAG. Median time to reach a POAG end point was 72.3 months. The 93 eyes of 388 participants not reaching endpoint were followed for a median of 124.9 months. Baseline GPS identified many more eyes as outside normal limits than the MRA. In multivariable analyses, all regional and globa...Continue Reading

Associated Clinical Trials

References

Jan 1, 1991·Journal of Clinical Epidemiology·D L SimelD B Matchar
Aug 26, 1998·Ophthalmology·G WollsteinR A Hitchings
Jan 14, 2004·Archives of Ophthalmology·Linda M ZangwillUNKNOWN Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study
Feb 14, 2004·American Journal of Ophthalmology·Linda M ZangwillUNKNOWN OHTS CSLO Ancillary Study Group
Nov 11, 2006·Ophthalmology·UNKNOWN Ocular Hypertension Treatment Study GroupMichael A Kass
Nov 24, 2006·Investigative Ophthalmology & Visual Science·Annemiek CoopsPaul Habib Artes
Apr 26, 2008·Investigative Ophthalmology & Visual Science·Luciana M AlencarFelipe A Medeiros

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Citations

Oct 4, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J Stürmer
Nov 1, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J Wahl
Dec 18, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A G M JünemannR Rejdak
Dec 1, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Pui Yi Boey, Steven L Mansberger
Mar 8, 2016·Ophthalmology·HannaMaria ÖhnellBoel Bengtsson
Sep 20, 2011·American Journal of Ophthalmology·Marc F LiebermanMingguang He
Aug 1, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E M Hoffmann
Mar 19, 2013·American Journal of Ophthalmology·Linda M ZangwillUNKNOWN Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study
Jun 13, 2015·Asia-Pacific Journal of Ophthalmology·Mohsen YaghoubiFarhad Shokraneh
Aug 3, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nayuta YoshiokaBarbara Zangerl
Jan 1, 2016·Expert Review of Ophthalmology·Katie A Lucy, Gadi Wollstein
Oct 6, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Frances Meier-Gibbons, Marc Töteberg-Harms

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