Predicting the risk of multiple endocrine neoplasia type 1 for patients with commonly occurring endocrine tumors

European Journal of Endocrinology
Joanne M de LaatG D Valk

Abstract

Endocrine diseases that can be part of the rare inheritable syndrome multiple endocrine neoplasia type 1 (MEN1) commonly occur in the general population. Patients at risk for MEN1, and consequently their families, must be identified to prevent morbidity through periodic screening for the detection and treatment of manifestations in an early stage. The aim of the study was to develop a model for predicting MEN1 in individual patients with sporadically occurring endocrine tumors. Cross-sectional study. In a nationwide study in The Netherlands, patients with sporadically occurring endocrine tumors in whom the referring physician suspected the MEN1 syndrome were identified between 1998 and 2011 (n=365). Logistic regression analysis with internal validation using bootstrapping and external validation with a cohort from Sweden was used. A MEN1 mutation was found in 15.9% of 365 patients. Recurrent primary hyperparathyroidism (pHPT; odds ratio (OR) 162.40); nonrecurrent pHPT (OR 25.78); pancreatic neuroendocrine tumors (pNETs) and duodenal NETs (OR 17.94); pituitary tumor (OR 4.71); NET of stomach, thymus, or bronchus (OR 25.84); positive family history of NET (OR 4.53); and age (OR 0.96) predicted MEN1. The c-statistic of the predict...Continue Reading

Citations

Jan 3, 2013·Asia-Pacific Journal of Clinical Oncology·Richard W Carroll
Aug 5, 2017·Endocrine-related Cancer·Rachel S van LeeuwaardeGerlof D Valk
Feb 1, 2018·World Journal of Surgery·Nancy D Perrier
Oct 24, 2018·Endocrine Connections·Dirk-Jan van BeekGerlof D Valk
Jun 11, 2014·The Journal of Clinical Endocrinology and Metabolism·Joanne M de LaatGerlof D Valk
Oct 10, 2015·Langenbeck's Archives of Surgery·Maurizio IacoboneMenno Vriens
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Carolina R C PietermanGerlof D Valk
Jan 12, 2016·The Journal of Clinical Endocrinology and Metabolism·Rachel S van LeeuwaardeGerlof D Valk
Aug 8, 2015·The Journal of Clinical Endocrinology and Metabolism·Sjoerd NellGerlof D Valk
Jul 1, 2020·Zentralblatt für Chirurgie·Florian BöschJens Werner
Feb 23, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elfi B ConemansGerlof D Valk
Jun 6, 2012·Nature Reviews. Endocrinology·Lian Evans
Feb 26, 2019·Therapeutic Advances in Endocrinology and Metabolism·Marina TsoliGregory Kaltsas
Sep 27, 2018·Frontiers in Endocrinology·Joanne M de LaatGerlof D Valk
Jul 5, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan D WassermanJoshua D Schiffman
Feb 11, 2021·Nature Reviews. Endocrinology·Abdallah Al-SalamehPhilippe Chanson
May 5, 2020·Neuroendocrinology·Rachel S van LeeuwaardeGerlof D Valk

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