Predicting the strongest domain-domain contact in interacting protein pairs.

Statistical Applications in Genetics and Molecular Biology
Tom M W NyeSarah A Teichmann

Abstract

Experiments to determine the complete 3-dimensional structures of protein complexes are difficult to perform and only a limited range of such structures are available. In contrast, large-scale screening experiments have identified thousands of pairwise interactions between proteins, but such experiments do not produce explicit structural information. In addition, the data produced by these high through-put experiments contain large numbers of false positive results, and can be biased against detection of certain types of interaction. Several methods exist that analyse such pairwise interaction data in terms of the constituent domains within proteins, scoring pairs of domain superfamilies according to their propensity to interact. These scores can be used to predict the strongest domain-domain contact (the contact with the largest surface area) between interacting proteins for which the domain-level structures of the individual proteins are known. We test this predictive approach on a set of pairwise protein interactions taken from the Protein Quaternary Structure (PQS) database for which the true domain-domain contacts are known.While the overall prediction success rate across the whole test data set is poor, we shown how inter...Continue Reading

Citations

Jul 12, 2008·PLoS Computational Biology·Loïc RoyerMichael Schroeder
Oct 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beom Sik KangKu-Jin Kim

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