Predicting the treatment response of certolizumab for individual adult patients with rheumatoid arthritis: protocol for an individual participant data meta-analysis.

Systematic Reviews
Yan LuoToshi A. Furukawa

Abstract

A model that can predict treatment response for a patient with specific baseline characteristics would help decision-making in personalized medicine. The aim of the study is to develop such a model in the treatment of rheumatoid arthritis (RA) patients who receive certolizumab (CTZ) plus methotrexate (MTX) therapy, using individual participant data meta-analysis (IPD-MA). We will search Cochrane CENTRAL, PubMed, and Scopus as well as clinical trial registries, drug regulatory agency reports, and the pharmaceutical company websites from their inception onwards to obtain randomized controlled trials (RCTs) investigating CTZ plus MTX compared with MTX alone in treating RA. We will request the individual-level data of these trials from an independent platform (http://vivli.org). The primary outcome is efficacy defined as achieving either remission (based on ACR-EULAR Boolean or index-based remission definition) or low disease activity (based on either of the validated composite disease activity measures). The secondary outcomes include ACR50 (50% improvement based on ACR core set variables) and adverse events. We will use a two-stage approach to develop the prediction model. First, we will construct a risk model for the outcomes vi...Continue Reading

References

Sep 6, 2005·Arthritis and Rheumatism·Daniel AletahaJosef S Smolen
Mar 1, 2006·Rheumatic Diseases Clinics of North America·Daniel Aletaha, Josef S Smolen
Sep 2, 2008·Arthritis and Rheumatism·Daniel AletahaJosef S Smolen
Feb 9, 2010·BMJ : British Medical Journal·Richard D RileyGhada Abo-Zaid
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Apr 29, 2015·JAMA : the Journal of the American Medical Association·Lesley A StewartUNKNOWN PRISMA-IPD Development Group
Aug 20, 2015·Research Synthesis Methods·Thomas P A DebrayUNKNOWN GetReal Methods Review Group
Oct 16, 2015·PLoS Medicine·Thomas P A DebrayUNKNOWN Cochrane IPD Meta-analysis Methods group
Aug 7, 2016·Therapeutic Advances in Musculoskeletal Disease·Francisco EspinozaYves-Marie Pers
Jul 10, 2017·Mayo Clinic Proceedings·C A Wijbrandts, P P Tak
Apr 19, 2018·Expert Review of Clinical Immunology·Stephanie LingAnne Barton
Dec 12, 2018·BMJ : British Medical Journal·David M KentDavid van Klaveren
May 1, 2019·Annals of the Rheumatic Diseases·Athina SpiliopoulouPaul McKeigue
Aug 30, 2019·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Sep 4, 2019·BMC Medical Research Methodology·Michail BeliasJoanna IntHout

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Citations

Jan 23, 2021·JAMA Network Open·Joe V Selby, Bruce H Fireman

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Software Mentioned

Scopus
LASSO
MA
rcs
IPD

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