DOI: 10.1101/458273Nov 2, 2018Paper

Predicting time to dementia using a quantitative template of disease progression

BioRxiv : the Preprint Server for Biology
Murat Bilgel, Bruno M Jedynak


Introduction: Characterization of longitudinal trajectories of biomarkers implicated in sporadic Alzheimer's disease~(AD) in decades prior to clinical diagnosis is important for disease prevention and monitoring. Methods: We used a multivariate Bayesian model to temporally align 1369 AD Neuroimaging Initiative participants based on the similarity of their longitudinal biomarker measures and estimated a quantitative template of the temporal evolution cerebrospinal fluid (CSF) Aβ1-42, p-tau181p, and t-tau, hippocampal volume, brain glucose metabolism, and cognitive measurements. We computed biomarker trajectories as a function of time to AD dementia, and predicted AD dementia onset age in a disjoint sample. Results: Quantitative template showed earliest changes in verbal memory, followed by CSF Aβ1-42, hippocampal volume, and p-tau181p. Mean error in predicted AD dementia onset age was < 1.5 years. Discussion: Our method provides a quantitative approach for characterizing the natural history of AD starting at preclinical stages despite the lack of individual-level longitudinal data spanning the entire disease timeline.

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Alzheimer's Disease: Microglia (Preprints)

Microglial proliferation and activation, as well as its concentration around amyloid plaques, is a prominent feature of Alzheimer’s disease. Here is the latest research on microglia and Alzheimer’s disease.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.