Predicting treatment discontinuation among patients with multiple sclerosis: application of the transtheoretical model of change

Journal of the American Pharmacists Association : JAPhA
Bruce A BergerHuigang Liang

Abstract

To delineate factors associated with discontinued use of the multiple sclerosis (MS) medication Avonex (interferon beta-1a--Biogen) as part of an effort to develop an intervention to promote treatment persistency. In-depth telephone interviews followed by a 12-page written questionnaire delivered by mail. United States. Of 946 patients with MS who were contacted, 531 (56%) completed questionnaires; 79% of respondents were currently using Avonex for treatment of MS. Discontinuation of Avonex treatment, with analysis based on the theoretical framework of the Transtheoretical Model of Change. Four key variables (pros of Avonex use, cons of Avonex use, highest level of education completed, and level of disability) accurately identified 82% of patients who discontinued Avonex use, while also correctly identifying 81% of patients who stayed on the drug. Constructs from the Transtheoretical Model of Change were effective in differentiating patients who had discontinued their Avonex treatment versus patients who continued treatment. This behavioral model likely would be an effective framework for a medication persistency intervention.

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Citations

Feb 4, 2010·Journal of Behavioral Medicine·Jared M BruceSharon Lynch
Aug 6, 2013·Drugs & Aging·Emily ReeveMichael D Wiese
Jan 19, 2006·Advances in Therapy·Kem P KruegerBill Felkey
Nov 21, 2008·Journal of the American Pharmacists Association : JAPhA·Jennifer Elston LafataStanton Elias
Sep 1, 2005·Journal of the American Pharmacists Association : JAPhA·Bruce A BergerKaren Suchanek Hudmon
Sep 24, 2010·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Colleen A McHorney, Charles V Spain
Jun 22, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V DevonshireUNKNOWN GAP Study Group
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Dec 10, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Jared M BruceSharon G Lynch
Mar 5, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rebekah L HansonJoAnn Stubbings
Nov 6, 2010·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Christina CaonJennifer Shoemaker
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Apr 1, 2012·International Journal of MS Care·Raed Alroughani, Anil Thussu
Jun 3, 2020·Currents in Pharmacy Teaching & Learning·Michael A Biddle, Rebecca M Hoover

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