Predicting treatment efficacy via quantitative magnetic resonance imaging: a Bayesian joint model.

Journal of the Royal Statistical Society. Series C, Applied Statistics
Jincao WuBrian D Ross

Abstract

The prognosis for patients with high grade gliomas is poor, with a median survival of 1 year. Treatment efficacy assessment is typically unavailable until 5-6 months post diagnosis. Investigators hypothesize that quantitative magnetic resonance imaging can assess treatment efficacy 3 weeks after therapy starts, thereby allowing salvage treatments to begin earlier. The purpose of this work is to build a predictive model of treatment efficacy by using quantitative magnetic resonance imaging data and to assess its performance. The outcome is 1-year survival status. We propose a joint, two-stage Bayesian model. In stage I, we smooth the image data with a multivariate spatiotemporal pairwise difference prior. We propose four summary statistics that are functionals of posterior parameters from the first-stage model. In stage II, these statistics enter a generalized non-linear model as predictors of survival status. We use the probit link and a multivariate adaptive regression spline basis. Gibbs sampling and reversible jump Markov chain Monte Carlo methods are applied iteratively between the two stages to estimate the posterior distribution. Through both simulation studies and model performance comparisons we find that we can achieve...Continue Reading

References

Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A M ChinnaiyanA Rehemtulla
Dec 21, 2000·Journal of the National Cancer Institute·T L ChenevertB D Ross
Dec 19, 2002·NMR in Biomedicine·Peter J Basser, Derek K Jones
Sep 10, 2003·Journal of Neurosurgery·Edward R LawsUNKNOWN Glioma Outcomes Investigators
Apr 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bradford A MoffatBrian D Ross
Nov 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel A HamstraBrian D Ross
Jun 8, 2006·Neoplasia : an International Journal for Oncology Research·Bradford A MoffatBrian D Ross
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel A HamstraThomas L Chenevert
Apr 21, 2009·Nature Medicine·Craig J GalbánBrian D Ross

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