Predicting Treatment Response to Neoadjuvant Chemoradiotherapy in Rectal Mucinous Adenocarcinoma Using an MRI-Based Radiomics Nomogram.

Frontiers in Oncology
Zhihui LiJianping Lu

Abstract

To build and validate an MRI-based radiomics nomogram to predict the therapeutic response to neoadjuvant chemoradiotherapy (nCRT) in rectal mucinous adenocarcinoma (RMAC). Totally, 92 individuals with pathologically confirmed RMAC administered surgical resection upon nCRT in two different centers were assessed retrospectively (training set, n = 52, validation set, n = 40). Rectal MRI was performed pre-nCRT. Radiomics parameters were obtained from high-resolution T2-weighted images and selected to construct a radiomics signature. Then, radiomics nomogram construction integrated patient variables and the radiomics signature. The resulting radiomics nomogram was utilized to assess the tumor regression grade (TRG). Diagnostic performance was determined by generating receiver operating characteristic (ROC) curves and decision curve analysis (DCA). Six optimal features related to TRG were obtained to construct a radiomics signature. The nomogram combining the radiomics signature with age and mucin deposit outperformed the radiomics signature alone in the training (AUC, 0.950 vs 0.843, p < 0.05) and validation (AUC, 0.868 vs 0.719, p < 0.05) cohorts. DCA demonstrated a clinical utility for the radiomics nomogram model. The established...Continue Reading

References

Dec 1, 1995·British Journal of Cancer·C Hanski
Aug 31, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Uday B PatelGina Brown
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Aug 18, 2012·Magnetic Resonance Imaging·Virendra KumarRobert J Gillies
Jan 21, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stanley K T YuGina Brown
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Sep 2, 2015·Nature Reviews. Clinical Oncology·Niek HugenIris D Nagtegaal
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ke NieXiaonan Sun
Sep 25, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhenyu LiuYing-Shi Sun
May 20, 2018·Nature Reviews. Cancer·Ahmed HosnyHugo J W L Aerts
Jul 15, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Al B BensonDeborah A Freedman-Cass
Jan 9, 2019·Nature Medicine·W Nicholson Price, I Glenn Cohen
Apr 18, 2019·Abdominal Radiology·Natally HorvatIva Petkovska
Aug 23, 2019·Histopathology·Iris D NagtegaalUNKNOWN WHO Classification of Tumours Editorial Board
Mar 10, 2020·Seminars in Oncology·Bryan OronskySusan J Knox

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