Prediction and design of macromolecular structures and interactions

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
David Baker

Abstract

In this article, I summarize recent work from my group directed towards developing an improved model of intra and intermolecular interactions and applying this improved model to the prediction and design of macromolecular structures and interactions. Prediction and design applications can be of great biological interest in their own right, and also provide very stringent and objective tests which drive the improvement of the model and increases in fundamental understanding. I emphasize the results from the prediction and design tests that suggest progress is being made in high-resolution modelling, and that there is hope for reliably and accurately computing structural biology.

References

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Jan 12, 2002·Journal of Molecular Biology·Brian KuhlmanDavid Baker
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Citations

Jun 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sebastian PechmannMichele Vendruscolo
Jan 6, 2009·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Tamjidul HoqueAbdul Sattar
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Mar 10, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David T JonesJanet M Thornton
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Dec 4, 2012·Biopolymers·David V TulumelloCharles M Deber

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