Prediction and Management for Relapse of Type 1 Autoimmune Pancreatitis After Initial Steroid Treatment: A Long-Term Follow-up From China

Pancreas
Lei XinZhao-Shen Li

Abstract

This study aimed to investigate the frequency, predictors, and management of relapse of type 1 autoimmune pancreatitis (AIP) after steroid treatment. One hundred one patients with type 1 AIP receiving steroid as initial treatment were enrolled. Predictors were identified by multivariate analysis using Cox proportional hazards model. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated. Thirty-nine (41.1%) patients experienced relapse after steroid treatment during a median follow-up of 40 months. The cumulative rate of relapse reached a plateau at 57.6% (95% CI, 50.3%-64.9%) at 59 months. Without maintenance therapy (HR, 4.53; 95% CI, 1.35-15.17) and proximal bile duct involvement (HR, 2.10; 95% CI, 1.07-4.14) were identified as risk factors. Repeated steroid treatment with the same initial dose but longer induction and tapering duration was given to 87.2% patients with relapse and obtained response (97.1%) during a short-term follow-up (median, 19 months). Relapses are common in type 1 AIP after steroid treatment. Without maintenance therapy and proximal bile duct involvement were risk factors. Repeated steroid treatment with longer duration is effective for relapse.

References

Jul 16, 1999·Lancet·G W ErkelensS D van der Werf
Jul 1, 1961·The American Journal of Digestive Diseases·H SARLESC GUIEN
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Giuseppe ZamboniGünter Klöppel
Jul 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suresh T ChariMichael B Farnell
Jun 1, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Einar BjörnssonKeith Lindor
Jan 29, 2008·Gastroenterology·Amaar GhazaleMichael B Farnell
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark TopazianSuresh T Chari
Jul 5, 2008·Journal of Gastroenterology·Makoto OtsukiUNKNOWN Research Committee of Intractable Pancreatic Diseases provided by the Ministry of Health, Labour and Welfare of Japan and th
Apr 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Neomal S SandanayakeGeorge J M Webster
Apr 29, 2009·Gut·T KamisawaM Omata
Jun 18, 2009·The American Journal of Gastroenterology·Amit RainaAdam Slivka
Mar 10, 2010·Journal of Gastroenterology·Terumi KamisawaUNKNOWN Research Committee for Intractable Pancreatic Disease and Japan Pancreas Society
Jun 22, 2010·Pancreas·Suresh T ChariUNKNOWN Autoimmune Pancreatitis International Cooperative Study Group (APICS)
Aug 26, 2010·The American Journal of Gastroenterology·Frédérique MairePascal Hammel
Mar 18, 2011·Pancreas·Tooru ShimosegawaUNKNOWN International Association of Pancreatology
Feb 22, 2012·Current Gastroenterology Reports·Raghuwansh P Sah, Suresh T Chari
Mar 6, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Antonio López-SerranoUNKNOWN Members of the Autoimmune Pancreatitis in Spain Study Group
Aug 21, 2016·Gut·Atsushi MasamuneUNKNOWN Research Committee of Intractable Pancreas Diseases in Japan
Dec 29, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Kazuichi OkazakiTooru Shimosegawa

❮ Previous
Next ❯

Citations

Jan 8, 2020·International Journal of Molecular Sciences·Hiroyuki MatsubayashiHiroyuki Ono
Jun 7, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Seung Bae YoonMyung-Hwan Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

European Journal of Gastroenterology & Hepatology
Kensuke TakumaYoshinori Igarashi
Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Terumi KamisawaAtsutake Okamoto
Scandinavian Journal of Gastroenterology
Terumi KamisawaNorio Sawabu
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Caroline E WeibullIngrid Glimelius
© 2022 Meta ULC. All rights reserved