Prediction efficiency of serum cystatin C for clinical outcome in patients with cardiac resynchronization therapy

Irish Journal of Medical Science
Zhong-Bao RuanLi Zhu

Abstract

Since only 60-70% of select patients with chronic heart failure (CHF) are responders in cardiac resynchronization therapy (CRT), this study aimed to investigate whether serum cystatin C (Cys C) can be used to evaluate the effectiveness of CRT in patients with CHF. Seventy-six patients implanted with CRT were retrospectively enrolled. The concentration of serum Cys C was detected and echocardiography was performed before and after 15 days, 1 month, and 6 months of CRT. There were 52 patients (68.4%) who responded to CRT during the follow-up. In the responding group, compared with the pre-CRT, the cardiac function, QRS interval, left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and left ventricular ejection fraction (LVEF) were significantly improved at 6 months after implantation (P < 0.05), but the level of serum Cys C decreased significantly from 1 month after CRT. There was no change of all the parameters in the non-responding group during the follow-up. In the responding group, the ΔCys C% is significantly related to the ΔLVEDV%, ΔLVESV%, and ΔLVEF%. Multivariate linear analysis shows that the ΔCys C% is significantly related to the ΔLVEDV%. The level of serum Cys C before CRT impla...Continue Reading

References

Feb 20, 2016·Current Opinion in Pharmacology·Roberto LatiniSerge Masson
Sep 1, 2016·Scandinavian Cardiovascular Journal : SCJ·Marcus StåhlbergCecilia Linde
Dec 3, 2016·Journal of the American College of Cardiology·Paul M McKie, John C Burnett
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Feb 24, 2017·Indian Heart Journal·Sadegh Ali-Hassan-SayeghAron-Frederik Popov

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