Prediction model for 3-year rupture risk of unruptured cerebral aneurysms in Japanese patients

Annals of Neurology
Shinjiro TominariUnruptured Cerebral Aneurysm Study Japan Investigators

Abstract

To build a prediction model that estimates the 3-year rupture risk of unruptured saccular cerebral aneurysms. Survival analysis was done using each aneurysm as the unit for analysis. Derivation data were from the Unruptured Cerebral Aneurysm Study (UCAS) in Japan. It consists of patients with unruptured cerebral aneurysms enrolled between 2000 and 2004 at neurosurgical departments at tertiary care hospitals in Japan. The model was presented as a scoring system, and aneurysms were classified into 4 risk grades by predicted 3-year rupture risk: I, < 1%; II, 1 to 3%; III, 3 to 9%, and IV, >9%. The discrimination property and calibration plot of the model were evaluated with external validation data. They were a combination of 3 Japanese cohort studies: UCAS II, the Small Unruptured Intracranial Aneurysm Verification study, and the study at Jikei University School of Medicine. The derivation data include 6,606 unruptured cerebral aneurysms in 5,651 patients. During the 11,482 aneurysm-year follow-up period, 107 ruptures were observed. The predictors chosen for the scoring system were patient age, sex, and hypertension, along with aneurysm size, location, and the presence of a daughter sac. The 3-year risk of rupture ranged from <1%...Continue Reading

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References

May 14, 1982·JAMA : the Journal of the American Medical Association·F E HarrellR A Rosati
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·T W RaaymakersA Algra
Dec 29, 1998·The New England Journal of Medicine·UNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Apr 20, 2001·Medical Decision Making : an International Journal of the Society for Medical Decision Making·N AokiT Fukui
Jan 10, 2002·Statistics in Medicine·E W SteyerbergUNKNOWN ReHiT Study Group
Jul 18, 2003·Lancet·David O WiebersUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Mar 3, 2005·Journal of Neurosurgery·Madhavan L RaghavanRobert E Harbaugh
Mar 3, 2007·Stroke; a Journal of Cerebral Circulation·Marieke J H WermerGabriël J E Rinkel
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexia IasonosKatherine S Panageas
Oct 11, 2008·Stroke; a Journal of Cerebral Circulation·Toshihiro IshibashiToshiaki Abe
Dec 17, 2008·Current Neurology and Neuroscience Reports·Joseph D Burns, Robert D Brown
Jul 31, 2010·Stroke; a Journal of Cerebral Circulation·Makoto SonobeHaruhiko Kikuchi
Sep 24, 2010·Cerebrovascular Diseases·Yukinori AkiyamaNobuo Hashimoto
Sep 3, 2011·Lancet·Nayu IkedaKenji Shibuya
Apr 21, 2012·Stroke; a Journal of Cerebral Circulation·Haakon LindekleivEllisiv B Mathiesen
Jun 29, 2012·The New England Journal of Medicine·Akio MoritaTakashi Yoshimoto
Jan 29, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Monique H M VlakAle Algra

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Citations

May 11, 2016·Neurology·Tomoyuki KawadaAkio Morita
May 1, 2016·Annals of Neurology·Jens WitschJan Claassen
Feb 26, 2016·Stroke; a Journal of Cerebral Circulation·Daan BackesMervyn D I Vergouwen
Jan 27, 2019·Journal of Neurosurgery·Fusao IkawaUNKNOWN Japan Neurosurgical Society for UCAS Japan Investigators
Mar 16, 2019·Journal of Neurosurgery·Hormuzdiyar H DasenbrockRose Du
Oct 9, 2019·Journal of Stroke·Mayte Sánchez van KammenMervyn D I Vergouwen
Dec 10, 2019·Stroke; a Journal of Cerebral Circulation·Takashi SuzukiYuichi Murayama
Apr 2, 2017·Neurology·Daan BackesMervyn D I Vergouwen
Sep 6, 2019·International Journal of Computer Assisted Radiology and Surgery·Felicitas J DetmerJuan R Cebral
May 16, 2017·Journal of Cerebrovascular and Endovascular Neurosurgery·Myeong Cheol Kim, Sung-Kyun Hwang
Sep 14, 2019·Journal of Neurosurgery·Nobutaka HorieTakayuki Matsuo
Aug 18, 2020·Neurosurgical Review·Seifollah Gholampour, Saeed Mehrjoo
May 12, 2019·Neurocritical Care·Philippe BijlengaUNKNOWN Unruptured Cerebral Aneurysms and SAH CDE Project Investigators
Aug 30, 2019·Neurologia Medico-chirurgica·Fusao IkawaKaoru Kurisu
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Katharina A M HackenbergNima Etminan
Aug 11, 2018·International Journal of Computer Assisted Radiology and Surgery·Felicitas J DetmerJuan R Cebral
Jul 11, 2019·Stroke; a Journal of Cerebral Circulation·QingLin LiuYouXiang Li
Mar 10, 2019·Brain : a Journal of Neurology·Jae-Sik NamIn-Cheol Choi
Apr 8, 2020·Surgical Neurology International·Farrag MohammadKazunari Yoshida
Jul 28, 2020·Neurosurgical Review·Vittorio Stumpo, Carmelo Lucio Sturiale
Oct 31, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yeongu ChungWonhyoung Park
May 26, 2020·Deutsches Ärzteblatt International·Nima EtminanHelmuth Steinmetz
Apr 3, 2021·Journal of the Neurological Sciences·Jienan WangYueqi Zhu
Jul 3, 2021·AJNR. American Journal of Neuroradiology·K M TimminsI C van der Schaaf
Dec 11, 2021·Frontiers in Neurology·Kazim H NarsinhDaniel L Cooke

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