Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
K WermkerC Hallermann

Abstract

In patients with squamous cell carcinoma (SCC) of the lip, occurrence of lymph node metastasis (LNM) is more frequent than in other cutaneous head and neck SCCs. The aim of this study was to identify predictive factors for LNM in SCC of the lip and to establish a prediction model identifying patients at high LNM risk. Tumor characteristics of 326 patients with lip SCC were analyzed retrospectively to assess differences between the LNM group and controls. Using binary logistic and Cox regression analysis, a prediction model for LNM was calculated. Lymph node metastasis occurred in 26 (8%) patients. Regression analysis revealed tumor extent, tumor depth and grading as the most important factors in the correct classification of LNM in 94.2% of patients. A prediction model taking tumor depth and grading into account allowed for stratification of patients into high and low risk groups (sensitivity 92.3%, specificity 78.3%, negative predictive value 99.2%). Our new prediction model was able to identify patients with lip cancer who had a high risk of LNM with a good level of accuracy. This algorithm is easy to apply as part of the decision process for elective and selective lymph node dissection in SCC of the lip.

References

May 1, 1992·American Journal of Surgery·G I McGregorJ H Hay
Dec 1, 1987·Plastic and Reconstructive Surgery·C W Cruse, R F Radocha
Apr 1, 1973·Acta Oto-laryngologica·K JorgensenA P Andersen
Nov 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R P ZitschJ L Rea
Feb 1, 1994·Journal of Cutaneous Pathology·A L Stein, S R Tahan
Sep 1, 1993·Archives of Otolaryngology--head & Neck Surgery·L P KowalskiH Torloni
Jul 15, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J G de VisscherI van der Waal
Sep 17, 1998·Archives of Otolaryngology--head & Neck Surgery·H T HoffmanH R Menck
Jul 14, 1999·Head & Neck·R P ZitschR B Smith
Aug 9, 2002·Oral Oncology·María Teresa Canto, Susan S Devesa
Jan 20, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Alexandru Bucur, Lidia Stefanescu
Oct 29, 2004·Oral Oncology·Kuauhyama Luna-OrtizAdalberto Mosqueda-Taylor
Mar 21, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Miroslav VukadinovicMarko Lens
Jul 9, 2008·Acta Oto-laryngologica·Carlos T ChoneAgricio N Crespo
Sep 26, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Helmut BreuningerClaus Garbe
Mar 24, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Attilio Carlo SalgarelliMarco Collini
Dec 1, 2009·Experimental and Molecular Pathology·Ericka Janine Dantas da SilveiraLélia Maria Guedes Queiroz
Feb 19, 2010·The British Journal of Dermatology·R CzerninskiH D Sgan-Cohen
Mar 12, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Aline Carvalho BatistaTarcília Aparecida Silva
May 11, 2011·Expert Review of Anticancer Therapy·Venura SamarasingheJohn T Lear
Jun 26, 2012·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Matthias KreppelMartin Scheer
Mar 27, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Rory O'ConnorMark McGurk
Feb 18, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Zhien FengChuan Bin Guo
Sep 2, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Chuan Bin GuoLi Xuan Niu
Sep 12, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Shuang ShiChangfu Sun

❮ Previous
Next ❯

Citations

Mar 8, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Josué HernandoLuís Junquera
Aug 9, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ulrich StrassenAndreas Knopf
Feb 6, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·James P BotaBryan T Carroll
Jan 9, 2018·International Journal of Applied & Basic Medical Research·Padmaraj HegdeUrvashi Shetty
Jun 5, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Norberto K KavabataCláudio R Cernea
Mar 23, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brianna N HarrisArnaud F Bewley
Jun 6, 2017·Head & Neck·William DoughertyUNKNOWN Education Committee of the American Head and Neck Society
Aug 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Federica RocchettiUmberto Romeo
Feb 13, 2020·Deutsches Ärzteblatt International·Ralf GutzmerCarola Berking
Mar 30, 2021·Frontiers in Oncology·Yassine AabouboutSenada Koljenović
May 7, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Priscilla J TanamalAndrew T Day
Jun 19, 2021·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·M KleinA Modabber
Aug 31, 2021·The British Journal of Oral & Maxillofacial Surgery·C CopelliR Cocchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Eugenio MiraElisabetta Zanoletti
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Pei-Rong DingZhi-Zhong Pan
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
K WermkerC Hallermann
Revista do Colégio Brasileiro de Cirurgiões
Rogério Aparecido DedivitisElio Gilberto Pfuetzenreiter
© 2022 Meta ULC. All rights reserved