Prediction models for neonatal health care-associated sepsis: a meta-analysis

Pediatrics
Evelien Hilde VerstraeteStijn Blot

Abstract

Blood culture is the gold standard to diagnose bloodstream infection but is usually time-consuming. Prediction models aim to facilitate early preliminary diagnosis and treatment. We systematically reviewed prediction models for health care-associated bloodstream infection (HABSI) in neonates, identified superior models, and pooled clinical predictors. LibHub, PubMed, and Web of Science. The studies included designed prediction models for laboratory-confirmed HABSI or sepsis. The target population was a consecutive series of neonates with suspicion of sepsis hospitalized for ≥ 48 hours. Clinical predictors had to be recorded at time of or before culturing. Methodologic quality of the studies was assessed. Data extracted included population characteristics, total suspected and laboratory-confirmed episodes and definition, clinical parameter definitions and odds ratios, and diagnostic accuracy parameters. The systematic search revealed 9 articles with 12 prediction models representing 1295 suspected and 434 laboratory-confirmed sepsis episodes. Models exhibit moderate-good methodologic quality, large pretest probability range, and insufficient diagnostic accuracy. Random effects meta-analysis showed that lethargy, pallor/mottling,...Continue Reading

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Citations

Aug 6, 2015·The Pediatric Infectious Disease Journal·Evelien Hilde VerstraeteStijn Blot
Apr 28, 2016·European Journal of Pediatrics·Evelien Hilde VerstraeteStijn Blot
Nov 6, 2018·Journal of Clinical Periodontology·Mi DuMarco A Peres
Jan 15, 2019·The Cochrane Database of Systematic Reviews·Jennifer Valeska Elli BrownWilliam McGuire
May 16, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Anna PalatnikLynn M Yee
Sep 14, 2017·Expert Review of Anti-infective Therapy·Elsa Da Palma Afonso, Stijn Blot
Apr 13, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ioannis BellosVasilios Pergialiotis
Jul 28, 2018·European Journal of Pediatrics·Evelien Hilde VerstraeteStijn Blot
Mar 31, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Samantha Eschborn, Joern-Hendrik Weitkamp
Mar 24, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Ori GoldbergGil Klinger
Feb 20, 2020·BMC Infectious Diseases·Dominicus HusadaJaranit Kaewkungwal
Feb 4, 2021·Critical Care Explorations·Laura Cabrera-QuirosCarola van Pul

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