Prediction of 90-day mortality after surgery for colorectal cancer using standardized nationwide quality-assurance data.

BJS Open
R P VogelsangIsmail Gögenur

Abstract

Personalized risk assessment provides opportunities for tailoring treatment, optimizing healthcare resources and improving outcome. The aim of this study was to develop a 90-day mortality-risk prediction model for identification of high- and low-risk patients undergoing surgery for colorectal cancer. This was a nationwide cohort study using records from the Danish Colorectal Cancer Group database that included all patients undergoing surgery for colorectal cancer between 1 January 2004 and 31 December 2015. A least absolute shrinkage and selection operator logistic regression prediction model was developed using 121 pre- and intraoperative variables and internally validated in a hold-out test data set. The accuracy of the model was assessed in terms of discrimination and calibration. In total, 49 607 patients were registered in the database. After exclusion of 16 680 individuals, 32 927 patients were included in the analysis. Overall, 1754 (5.3 per cent) deaths were recorded. Targeting high-risk individuals, the model identified 5.5 per cent of all patients facing a risk of 90-day mortality exceeding 35 per cent, corresponding to a 6.7 times greater risk than the average population. Targeting low-risk individuals, the model ide...Continue Reading

References

Mar 1, 1991·The British Journal of Surgery·G P CopelandM Walters
Sep 28, 2004·The British Journal of Surgery·P P TekkisA C J Windsor
Jan 27, 2007·Journal of the American College of Surgeons·Atul A GawandeMichael J Zinner
Jul 16, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·O H SjoA Nesbakken
Aug 20, 2009·JAMA : the Journal of the American Medical Association·Mike Mitka
Nov 18, 2009·Archives of Surgery·Brendan C VisserSherry M Wren
Jun 22, 2012·The British Journal of Surgery·R A M DamhuisJ J van Lanschot
Jan 1, 2013·ACM Transactions on Modeling and Computer Simulation : a Publication of the Association for Computing Machinery·Marc A SuchardDavid Madigan
Dec 20, 2014·The British Journal of Surgery·K WalkerJ H van der Meulen
Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·George HripcsakDavid Madigan
Nov 9, 2016·Clinical Epidemiology·Peter IngeholmLene H Iversen
Apr 27, 2017·The New England Journal of Medicine·Ravi B ParikhAmol S Navathe
Jun 11, 2017·American Journal of Surgery·Mohamed Abdelgadir AdamChristopher R Mantyh
May 3, 2018·Journal of the American Medical Informatics Association : JAMIA·Jenna M RepsPeter R Rijnbeek
Oct 18, 2018·International Journal of Colorectal Disease·Thea Helene DegettIsmail Gögenur
Apr 4, 2019·The New England Journal of Medicine·Alvin RajkomarIsaac Kohane
May 6, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jenna M RepsPatrick B Ryan
May 17, 2019·Diagnostic and Prognostic Research·Teus H KappenKarel G M Moons
Nov 13, 2019·JAMA : the Journal of the American Medical Association·Finale Doshi-Velez, Roy H Perlis

❮ Previous
Next ❯

Software Mentioned

PatientLevelPrediction
OhdsiRTools
R Foundation for Statistical Computing
Cyclops
OMOP Data Model
ATLAS
Surgical Risk Calculator
Observational Science and Informatics ( )
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.