Prediction of a novel RNA binding domain in crocodilepox Zimbabwe Gene 157.

Microbial Informatics and Experimentation
Nicole S LittleC Upton

Abstract

Although the crocodilepox virus (CRV) is currently unclassified, phylogenetic analyses suggest that its closest known relatives are molluscum contagiosum virus (MCV) and the avipox viruses. The CRV genome is approximately 190 kb and contains a large number of unique genes in addition to the set of conserved Chordopoxvirus genes found in all such viruses. Upon sequencing the viral genome, others noted that this virus was also unusual because of the lack of a series of common immuno-suppressive genes. However, the genome contains multiple genes of unknown function that are likely to function in reducing the anti-viral response of the host. By using sensitive database searches for similarity, we observed that gene 157 of CRV-strain Zimbabwe (CRV-ZWE) encodes a protein with a domain that is predicted to bind dsRNA. Domain characterization supported this prediction, therefore, we tested the ability of the Robetta protein structure prediction server to model the amino acid sequence of this protein on a well-characterized RNA binding domain. The model generated by Robetta suggests that CRV-ZWE-157 does indeed contain an RNA binding domain; the model could be overlaid on the template protein structure with high confidence. We hypothesi...Continue Reading

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Software Mentioned

InterProScan
Gene3D
Viral Genome Organizer ( VGO
PyMOL Solver BLASTp
BLASTp
HHPred
MUSCLE MSA editor
JMol
Robetta
Jpred

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