Prediction of Adverse Outcomes in Pediatric Acute Hematogenous Osteomyelitis.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Zaid AlhinaiIan C Michelow

Abstract

Clinicians cannot reliably predict complications of acute hematogenous osteomyelitis (AHO). Consecutive cases of AHO from 2 pediatric centers in the United States were analyzed retrospectively to develop clinical tools from data obtained within 96 hours of hospitalization to predict acute and chronic complications of AHO. Two novel composite prediction scores derived from multivariable logistic regression modeling were compared with a previously published severity of illness (SOI) score, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) using area under the receiver operating characteristic curve analyses. The causative organisms were identified in 73% of 261 cases. Bacteremia (45%), abscesses (38%), and associated suppurative arthritis (23%) were relatively common. Acute or chronic complications occurred in 24% and 11% of patients, respectively. Multivariable logistic regression identified bone abscess (odds ratio [OR], 2.3 [95% confidence interval {CI}, 1.0-5.2]), fever > 48 hours (OR, 2.7 [95% CI, 1.2-6.0]), suppurative arthritis (OR, 3.2 [95% CI, 1.3-7.5]), disseminated disease (OR, 4.6 [95% CI, 1.5-14.3]), and delayed source control (OR, 5.1 [95% CI, 1.4-19.0]) as strong predictors of acute complications. ...Continue Reading

References

May 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I RoineF Rodriguez
Dec 14, 2006·Clinical Pediatrics·Richard Bachur, Zrinka Pagon
Jul 2, 2009·Journal of Pediatric Orthopedics·Nikolas Alan JagodzinskiChristopher Edward Bache
Sep 16, 2010·The Pediatric Infectious Disease Journal·Heikki PeltolaUNKNOWN Osteomyelitis-Septic Arthritis Study Group
Jan 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine LiuUNKNOWN Infectious Diseases Society of America
Dec 23, 2011·The Pediatric Infectious Disease Journal·Angela BarrierC Buddy Creech
Jan 4, 2013·Current Opinion in Pediatrics·Emily R Dodwell
Apr 19, 2013·The Journal of Bone and Joint Surgery. American Volume·Lawson A B CopleyRichard Browne
Jan 24, 2014·The New England Journal of Medicine·Heikki Peltola, Markus Pääkkönen
Dec 17, 2014·JAMA Pediatrics·Ron KerenUNKNOWN Pediatric Research in Inpatient Settings Network
May 2, 2015·Journal of Pediatric Orthopedics·Andrew Chia Chen Chou, Arjandas Mahadev
Jul 7, 2015·JAMA Pediatrics·Ian C Michelow, Jason G Mandell
Aug 28, 2015·Infectious Disease Clinics of North America·John C Arnold, John S Bradley
Dec 5, 2015·Frontiers in Cellular and Infection Microbiology·Jérôme JosseSophie C Gangloff
Dec 17, 2015·The Pediatric Infectious Disease Journal·Andrew C MartinChristopher C Blyth
Apr 25, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M GijónP Rojo Conejo
Jun 15, 2016·Journal of Pediatric Orthopedics·Megan E MignemiJonathan G Schoenecker
Oct 16, 2016·Journal of Pediatric Orthopedics·Alexander G AtheyLawson A Copley
Mar 25, 2017·The Orthopedic Clinics of North America·Michael BenvenutiJonathan G Schoenecker
Mar 25, 2017·The Orthopedic Clinics of North America·Shawn S Funk, Lawson A B Copley
Jul 15, 2017·The Pediatric Infectious Disease Journal·Jesús Saavedra-LozanoAnton LeMair
Jan 2, 2018·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M LorrotE Grimprel
Feb 21, 2018·Journal of Pediatric Orthopedics·William T Davis, Shawn R Gilbert
Jan 18, 2019·Paediatrics & Child Health·Nicole Le Saux
Feb 13, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Chase McNeilSheldon L Kaplan
May 28, 2019·Open Forum Infectious Diseases·Nicolás W Cortés-Penfield, Prathit A Kulkarni

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Citations

Mar 28, 2021·The Journal of Pediatrics·Jumi YiIsaac Thomsen
Oct 2, 2021·Hospital Pediatrics·Kathryn E KylerJennifer L Goldman

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