PMID: 9170469Jun 1, 1997Paper

Prediction of adverse perinatal outcome by maternal serum screening for Down syndrome in an Asian population

Obstetrics and Gynecology
T T HsiehF J Hsieh

Abstract

To investigate the association between adverse perinatal outcomes and abnormal elevations of serum marker levels (alpha-fetoprotein [AFP] and free beta-hCG) or a false-positive screen for Down syndrome. Pregnancy outcome information was available for 5885 Taiwanese women under 35 years of age who had second-trimester maternal serum screening for Down syndrome, using AFP and free beta-hCG, and delivered a chromosomally normal fetus. Those with AFP at least 2.0 multiples of the median (MoM), free beta-hCG at least 2.5 MoM, or a false-positive screen (risk ratio at least 1:270) were identified, and the risk for adverse perinatal outcome was assessed. A serum AFP level at least 2.0 MoM (n = 176, 3.0%) was significantly associated with the occurrence of preterm delivery, low Apgar scores, small-for-gestational-age infants, low birth weight or very low birth weight, fetal death, premature rupture of membranes, oligohydramnios, and a higher incidence of perinatal mortality. A serum free beta-hCG level at least 2.5 MoM (n = 416, 7.1%) was significantly associated with low birth weight, an abnormally adherent placenta, and the occurrence of meconium-stained amniotic fluid. A higher incidence of fetal structural anomalies other than neur...Continue Reading

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Citations

Apr 24, 1999·Obstetrics and Gynecology·T H HungT T Hsieh
Sep 13, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Emanuela MeddaUNKNOWN EUROPOP Group Sweden
Jun 28, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A J AntsaklisS S Michalas
Mar 19, 2004·The Journal of Perinatal & Neonatal Nursing·Marta C WilleStephanie Frazier
Nov 13, 2004·Fetal Diagnosis and Therapy·Bojana Brajenović-MilićMiljenko Kapović
Nov 24, 2005·American Journal of Public Health·Cande V AnanthMichael S Kramer
Sep 22, 2016·Journal of Obstetrics and Gynaecology of India·Koumudi GodboleAnuradha Wakankar
Nov 19, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Silvia So-Aei LiuSu-Chee Chen
Oct 7, 2008·The Journal of Obstetrics and Gynaecology Research·Sorahiro SunagawaAkihiko Kikuchi
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ambarina S FaizGeorge G Rhoads
Jan 15, 2013·American Journal of Obstetrics and Gynecology·Emmanuel SpaggiariFrançoise Muller
Oct 28, 2004·American Journal of Obstetrics and Gynecology·David KrantzUNKNOWN First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group
Mar 18, 2011·Fetal Diagnosis and Therapy·Jarek BetaKypros H Nicolaides
May 16, 2003·Prenatal Diagnosis·T HuangN J Wald
Jul 11, 2007·Prenatal Diagnosis·Ramesh GanapathyPaul Bassett
Apr 5, 2008·American Journal of Medical Genetics. Part a·Aidan Thomas, Edmond G Lemire
Jan 26, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T Y LeungT K Lau
Mar 8, 2006·Journal of Perinatal Medicine·Zehra Nese KavakHusnu Gokaslan
Jul 28, 2021·Journal of Perinatal Medicine·Meryl M SperlingKelly Yamasato

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