Prediction of age at onset in Parkinson's disease using objective specific neuroimaging genetics based on a sparse canonical correlation analysis.

Scientific Reports
Ji Hye WonHyunjin Park

Abstract

The age at onset (AAO) is an important determinant in Parkinson's disease (PD). Neuroimaging genetics is suitable for studying AAO in PD as it jointly analyzes imaging and genetics. We aimed to identify features associated with AAO in PD by applying the objective-specific neuroimaging genetics approach and constructing an AAO prediction model. Our objective-specific neuroimaging genetics extended the sparse canonical correlation analysis by an additional data type related to the target task to investigate possible associations of the imaging-genetic, genetic-target, and imaging-target pairs simultaneously. The identified imaging, genetic, and combined features were used to construct analytical models to predict the AAO in a nested five-fold cross-validation. We compared our approach with those from two feature selection approaches where only associations of imaging-target and genetic-target were explored. Using only imaging features, AAO prediction was accurate in all methods. Using only genetic features, the results from other methods were worse or unstable compared to our model. Using both imaging and genetic features, our proposed model predicted the AAO well (r = 0.5486). Our findings could have significant impacts on the c...Continue Reading

References

Apr 8, 2000·Gerontology·H NagayamaY Katayama
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·C H JiangY Hu
Apr 23, 2003·Archives of Neurology·Nico J DiederichChristopher G Goetz
Nov 26, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Anette SchragMarjan Jahanshahi
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Oct 22, 2008·Biochimica Et Biophysica Acta·Talene A Yacoubian, David G Standaert
Feb 4, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M M WickremaratchiH R Morris
Jul 4, 2009·Statistical Applications in Genetics and Molecular Biology·Daniela M Witten, Robert J Tibshirani
May 3, 2011·Current Aging Science·Brian C Clark, Janet L Taylor
Jun 10, 2011·Bioinformatics·Petr DanecekUNKNOWN 1000 Genomes Project Analysis Group
Sep 21, 2011·Progress in Neurobiology·UNKNOWN Parkinson Progression Marker Initiative
Apr 10, 2012·CNS & Neurological Disorders Drug Targets·Fabio SambataroRobert Christian Wolf
Feb 15, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Stephan KlebeUNKNOWN International Parkinson's Disease Genomics Consortium (IPDGC)
Sep 3, 2013·Neurology·Brit MollenhauerUNKNOWN DeNoPa Study Group
Dec 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Claustre Pont-SunyerEduardo Tolosa
Aug 10, 2015·Neuropsychology Review·Bryon A MuellerJazmin Camchong
Feb 13, 2016·Neurology·Gennaro PaganoNicola Pavese
Jul 13, 2016·Human Molecular Genetics·Erin M Hill-BurnsHaydeh Payami
Mar 16, 2017·Scientific Reports·Xiaoke HaoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 6, 2017·Journal of Neural Transmission·Beatrice HeimKlaus Seppi
Aug 3, 2017·NeuroImage. Clinical·Cyril Atkinson-ClementOlivier Coulon
Nov 6, 2017·Journal of Parkinson's Disease·Keerthi Thirtamara-RajamaniLena Brundin
Nov 24, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Nacim BetrouniKathy Dujardin

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Methods Mentioned

BETA
genotyping

Software Mentioned

BCFtools
mRMR
os
FMRIB Analysis Group Software Library FSL
FSL
WebGestalt
ENIGMA
PLINK
SCCA
LASSO

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