Prediction of aortic augmentation index using radial pulse transmission-wave analysis

Journal of Hypertension
Elizabeth O Y LauChu-Pak Lau

Abstract

Current arterial transfer functions have low capability in predicting aortic augmentation index (AIx) from radial pulse contour (RPC), because of the difficulty in accurately identifying the merging point (inflection point) in the derived aortic pulse contour (APC). We hypothesize that the formation time between each characteristic wave in APC is about one-third of ejection duration (ED/3). We sought to assess the accuracy of ED/3 in identifying the merging point in APC as compared to the conventional differential method. In addition, we sought to derive the AIx from RPC based on an arterial transfer function and the ED/3 method. APC and RPC sequences were measured digitally and simultaneously in 60 subjects (37 males; aged 60 +/- 10 years). An ensemble-averaged RPC-to-APC transfer function was determined from 30 randomly selected subjects and was used to derive APC sequences in the 30 additional subjects. The accuracy of AIx predicted from RPC was determined. In patients with a clearly identifiable merging point in APC, the ED/3 method identified the merging point of measured APC within 1.97 +/- 0.60 ms of that identified by the conventional differential method, with identical AIx. The AIx and merging point of derived APC usin...Continue Reading

References

Aug 1, 1995·Hypertension·M A JamesJ D Swales
Apr 6, 2001·Journal of Hypertension·J AmarJ Ferrières
Apr 13, 2001·Journal of the American College of Cardiology·H SmulyanM E Safar
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Apr 16, 2003·Hypertension·Sandrine C MillasseauPhilip J Chowienczyk
Jun 21, 2003·Journal of Hypertension·Arnold P HoeksRuben Dammers

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Citations

Feb 22, 2008·Journal of Cardiovascular Pharmacology·Denis ChemlaAlain Nitenberg

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