Prediction of arrhythmic events with positron emission tomography: PAREPET study design and methods

Contemporary Clinical Trials
J A FallavollitaJ M Canty

Abstract

In medically-treated patients with ischemic cardiomyopathy, myocardial viability is associated with a worse prognosis than scar. The risk is especially great with hibernating myocardium (chronic regional dysfunction with reduced resting flow), and the excess mortality appears to be due to sudden cardiac death (SCD). Hibernating myocardium also results in sympathetic nerve dysfunction, which has been independently associated with risk of SCD. PAREPET is a prospective, observational cohort study funded by NHLBI. It is designed to determine whether hibernating myocardium and/or inhomogeneity of sympathetic innervation by positron emission tomography imaging identifies patients with ischemic cardiomyopathy who are at high risk for SCD and cardiovascular mortality. Patients with documented ischemic cardiomyopathy, an ejection fraction of <or=35%, and with no plans for coronary revascularization will be recruited. Major exclusion criteria include: history of resuscitated SCD, sustained VT, ICD discharge, or unexplained syncope; recent myocardial infarction (30 days), percutaneous coronary intervention (3 months), coronary bypass surgery (1 year); or comorbidities that would be expected to reduce life expectancy to <2 years. All patie...Continue Reading

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Citations

Nov 11, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James A FallavollitaJohn M Canty
Apr 14, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James A FallavollitaJohn M Canty
Sep 22, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James A Fallavollita, John M Canty
Dec 2, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Iosif Kelesidis, Mark I Travin
Nov 28, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James T Thackeray, Frank M Bengel
Nov 29, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mark I Travin
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