PMID: 3761023Sep 1, 1986Paper

Prediction of brain and serum free amino acid profiles in rats fed graded levels of protein

The Journal of Nutrition
J M GustafsonL P Mercer

Abstract

Daily weight gains and food intakes were measured in male, 120-g rats fed graded levels of dietary casein. After 14 d, serum and brain amino acid concentrations were measured. All physiological responses were tested for a functional relationship to dietary casein concentration. Food intake, weight gain and many serum amino acid profiles were shown to be saturable functions of percent casein in the diet. In general, essential amino acids increased in serum with increasing dietary casein concentration while nonessential amino acids decreased with increasing dietary casein concentration. Brain amino acid concentrations were shown to be linear functions of serum levels with the exceptions of phenylalanine and the acidic amino acids. Most amino acids showed a smaller range of values in brain than in serum. The exceptions were the levels of threonine, glutamine, serine and histidine, which were three times greater in brain than in serum. Brain levels of the neutral amino acids tryptophan and tyrosine were highly correlated with the amino acid/neutral amino acid ratios in serum, whereas leucine was negatively correlated. Brain histidine, which was inversely correlated with dietary casein, was found to correlate with specific food inta...Continue Reading

Citations

Sep 7, 2002·Molecular and Cellular Biology·Peichuan ZhangDouglas R Cavener
Mar 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·Christopher D MorrisonRoy J Martin
Mar 25, 2011·Journal of Animal Physiology and Animal Nutrition·Tapas K MandalMitali Saha
Oct 28, 1999·The Journal of Nutrition·N TorresA R Tovar
May 22, 2007·The Journal of Nutrition·John D Fernstrom, Madelyn H Fernstrom

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