Prediction of brain deformations and risk of traumatic brain injury due to closed-head impact: quantitative analysis of the effects of boundary conditions and brain tissue constitutive model

Biomechanics and Modeling in Mechanobiology
Fang WangAdam Wittek

Abstract

In this study, we investigate the effects of modelling choices for the brain-skull interface (layers of tissues between the brain and skull that determine boundary conditions for the brain) and the constitutive model of brain parenchyma on the brain responses under violent impact as predicted using computational biomechanics model. We used the head/brain model from Total HUman Model for Safety (THUMS)-extensively validated finite element model of the human body that has been applied in numerous injury biomechanics studies. The computations were conducted using a well-established nonlinear explicit dynamics finite element code LS-DYNA. We employed four approaches for modelling the brain-skull interface and four constitutive models for the brain tissue in the numerical simulations of the experiments on post-mortem human subjects exposed to violent impacts reported in the literature. The brain-skull interface models included direct representation of the brain meninges and cerebrospinal fluid, outer brain surface rigidly attached to the skull, frictionless sliding contact between the brain and skull, and a layer of spring-type cohesive elements between the brain and skull. We considered Ogden hyperviscoelastic, Mooney-Rivlin hyperv...Continue Reading

References

Jan 1, 1993·Neurosurgery·D E HainesO al-Mefty
Feb 11, 1998·Journal of Biomechanics·K Miller, K Chinzei
Aug 15, 2000·Journal of Biomechanics·K MillerP Bednarz
Apr 6, 2002·Journal of Biomechanics·Karol Miller, Kiyoyuki Chinzei
May 24, 2003·Annals of Emergency Medicine·UNKNOWN National Highway Traffic Safety Administration
May 9, 2006·Journal of Biomechanics·Adam WittekSimon K Warfield
Apr 17, 2007·Journal of Biomechanics·Johnson Ho, Svein Kleiven
May 8, 2008·Accident; Analysis and Prevention·Daniel MarjouxRémy Willinger
May 28, 2010·Journal of the Royal Society, Interface·Y FengP V Bayly
Nov 23, 2010·Journal of Biomechanics·Xin JinAlbert I King
Jun 5, 2012·Annual Review of Biomedical Engineering·Philip V BaylyGuy M Genin
Aug 27, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Badar RashidMichael D Gilchrist
Sep 26, 2013·Journal of Biomechanical Engineering·Haojie MaoKing H Yang
Dec 11, 2013·Annals of Biomedical Engineering·Xin JinAlbert I King
Jan 28, 2014·Journal of Neurosurgery·Revanth Reddy GarlapatiKarol Miller
Dec 24, 2014·Annals of Biomedical Engineering·Fidel HernandezDavid B Camarillo
Aug 6, 2015·Computer Methods in Biomechanics and Biomedical Engineering·A LangletP Bailly
Aug 14, 2015·Acta neurochirurgica·Wouter PeetersAndrew I R Maas
Sep 12, 2015·Journal of the Royal Society, Interface·L Angela MihaiAlain Goriely
Oct 21, 2015·World Neurosurgery·Carlos Eduardo Romeu de AlmeidaBruno Silva Costa

❮ Previous
Next ❯

Citations

Aug 11, 2019·International Journal for Numerical Methods in Biomedical Engineering·Karol MillerAdam Wittek
Jan 24, 2019·Annals of Biomedical Engineering·Parisa Saboori, Graham Walker
Nov 1, 2018·Annals of Biomedical Engineering·J Sebastian GiudiceMatthew B Panzer
Apr 5, 2020·International Journal of Environmental Research and Public Health·Lihai RenYuanzhi Hu
Jan 23, 2021·International Journal for Numerical Methods in Biomedical Engineering·Harry DuckworthMazdak Ghajari
May 22, 2021·Frontiers in Bioengineering and Biotechnology·J Sebastian GiudiceMatthew B Panzer

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.