Prediction of cardiovascular events after renal transplantation

Transplantation Proceedings
Felix S SeibertTimm H Westhoff

Abstract

Pulse wave velocity (PWV) is a marker of arterial stiffness and predicts cardiovascular events in the nontransplantation population. Cardiovascular events (CVE) are the leading cause of death and one of the leading causes of graft failure in renal transplant recipients. The present prospective study investigates whether there is a correlation between PWV and CVE in renal transplant recipients. A prospective study assessing the incidence of a composite cardiovascular endpoint within ≥ 3 years after pulse wave analysis was performed in 64 stable renal transplant recipients. Measurement of PWV, augmentation index (AI75), and aortic systolic pressure was conducted using the SphygmoCor (AtCor) device. The composite endpoint of the study was the incidence of either death, myocardial infarction, stroke, or admission for symptomatic intermittent claudication or decompensated congestive heart failure. Fifteen patients (23%) reached the composite endpoint during a follow-up of 4.4 years. Binary logistic regression using PWV, AI75, central aortic systolic pressure, peripheral systolic pressure, and pulse pressure as covariates revealed that PWV was significantly associated with cardiovascular events (10.1 ± 3.6 m/s in subjects reaching th...Continue Reading

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Citations

Jul 26, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sharlene A GreenwoodIain C Macdougall
Feb 13, 2019·Journal of Hypertension·Marie-Pier DesjardinsMohsen Agharazii
Jan 12, 2020·International Urology and Nephrology·Sujuan FengXiaodong Zhang
Oct 7, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andras T DeakAlexander R Rosenkranz

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