Prediction of Chlamydia pneumoniae protein localization in host mitochondria and cytoplasm and possible involvements in lung cancer etiology: a computational approach

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Aws AlshamsanKhalid Alsaleh

Abstract

Collecting evidence suggests that the intercellular infection of Chlamydia pneumoniae in lungs contributes to the etiology of lung cancer. Many proteins of Chlamydia pneumoniae outmanoeuvre the various system of the host. The infection may regulate various factors, which can influence the growth of lung cancer in affected persons. In this in-silico study, we predict potential targeting of Chlamydia pneumoniae proteins in mitochondrial and cytoplasmic comportments of host cell and their possible involvement in growth and development of lung cancer. Various cellular activities are controlled in mitochondria and cytoplasm, where the localization of Chlamydia pneumoniae proteins may alter the normal functioning of host cells. The rationale of this study is to find out and explain the connection between Chlamydia pneumoniae infection and lung cancer. A sum of 183 and 513 proteins were predicted to target in mitochondria and cytoplasm of host cell out of total 1112 proteins of Chlamydia pneumoniae. In particular, many targeted proteins may interfere with normal growth behaviour of host cells, thereby altering the decision of program cell death. Present article provides a potential connection of Chlamydia pneumoniae protein targeting ...Continue Reading

Citations

Jan 8, 2019·Cancer Biomarkers : Section a of Disease Markers·Mingjing ShenZhongheng Xu
Jul 30, 2020·Mediators of Inflammation·Salah A Sheweita, Awad S Alsamghan
Dec 8, 2020·International Journal of Cancer. Journal International Du Cancer·Wanting LuZhijian Hu
Jun 3, 2021·Cancers·Miao SuEdouard C Nice

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Methods Mentioned

BETA
protein folding

Software Mentioned

Balanced Sub Cellular Localization predictor ( BaCeILo )
cNLS Mapper
BaCeILo
BaCelLo

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