Prediction of Chlamydia trachomatis infection: application of a scoring rule to other populations

Sexually Transmitted Diseases
Hannelore M GötzEwout W Steyerberg

Abstract

Active case finding is crucial to reduce transmission and consequences of Chlamydia trachomatis (CT) infections. We previously proposed the use of a prediction rule for CT infection for selective screening of high-risk individuals in a population. To support such an application, the prediction rule needs to be validated in other populations. We studied participants aged 15 to 29 years in a population-based study in Amsterdam (n = 1,788) and an outreach screening project among high-risk youth in Rotterdam (n = 172). Validity was indicated by discriminative ability (area under the receiver operating characteristic curve [AUC]) and by calibration, which was visualized in plots and tested with the Hosmer-Lemeshow (H-L) goodness-of-fit test. Cutoffs of predicted risk were examined for their effect on sensitivity and the fraction of participants that would need to be screened. Discriminative ability was reasonable both for the Amsterdam study (AUC 0.66; 95% confidence interval [CI], 0.58-0.74) and for the Rotterdam study (AUC 0.68; 95% CI, 0.58-0.79). The observed CT prevalence was lower than predicted in Amsterdam (H-L P = 0.02) and nonsignificantly higher in Rotterdam (H-L P = 0.20). By screening 77% of the Amsterdam population, 93...Continue Reading

References

Nov 1, 1990·Statistics in Medicine·J C Van Houwelingen, S Le Cessie
May 23, 1996·The New England Journal of Medicine·D ScholesW E Stamm
Jul 1, 1996·Journal of Clinical Epidemiology·F Harrell
Mar 13, 1999·Annals of Internal Medicine·A C JusticeJ A Berlin
Mar 1, 2000·Statistics in Medicine·D G Altman, P Royston
Feb 20, 2002·JAMA : the Journal of the American Medical Association·Charles F TurnerJonathan M Zenilman
May 2, 2002·Sexually Transmitted Diseases·Peter J BloomfieldJeffrey D Klausner
Feb 5, 2003·Sexually Transmitted Diseases·Maarit PaukkuJorma Paavonen
Feb 19, 2003·Journal of Clinical Epidemiology·Taane G Clark, Douglas G Altman
Mar 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Berit AndersenLars Østergaard
Jun 19, 2003·Journal of Clinical Epidemiology·Ewout W SteyerbergKarel G M Moons
Aug 7, 2003·Sexually Transmitted Infections·V VerhoevenP Van Royen
Dec 30, 2003·Sexually Transmitted Diseases·Carol A FordWilliam C Miller
Apr 27, 2004·Sexually Transmitted Diseases·D Scott La MontagneUNKNOWN Region X Infertility Prevention Project
Aug 3, 2004·Statistics in Medicine·Ewout W SteyerbergJ Dik F Habbema
Oct 2, 2004·Sexually Transmitted Infections·N LowM Egger
Feb 1, 2005·Sexually Transmitted Infections·H M GötzJ H Richardus
Mar 15, 2005·Scandinavian Journal of Infectious Diseases·Veronique VerhoevenMichel Stalpaert

❮ Previous
Next ❯

Citations

Aug 12, 2009·European Journal of Public Health·Lisa A KingJean-Claude Desenclos
Dec 5, 2013·JMIR Research Protocols·Titilola FalasinnuJean Shoveller
Apr 12, 2014·Sexually Transmitted Diseases·Titilola FalasinnuJean Shoveller
Apr 12, 2014·Sexually Transmitted Diseases·Hannelore Martha Götz, David van Klaveren
Jan 2, 2007·Current Opinion in Infectious Diseases·Jan Hendrik Richardus, Hannelore M Götz
Jan 13, 2015·Sexually Transmitted Diseases·Titilola FalasinnuJean Shoveller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Emergency Medicine
D R WiestJ M Bartfield
Sexual Health
Christopher K FairleyTim R H Read
Sexually Transmitted Infections
Christopher K Fairley
© 2021 Meta ULC. All rights reserved