Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index

Diabetologia
Andrea TuraMichael Roden

Abstract

The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield values different from those obtained by the clamp method. The aim of this study was to develop a new index to predict clamp-derived insulin sensitivity (M value) from the OGTT-derived oral glucose insulin sensitivity index (OGIS). We analysed datasets of people that underwent both a clamp and an OGTT or meal test, thereby allowing calculation of both the M value and OGIS. The population was divided into a training and a validation cohort (n = 359 and n = 154, respectively). After a stepwise selection approach, the best model for M value prediction was applied to the validation cohort. This cohort was also divided into subgroups according to glucose tolerance, obesity category and age. The new index, called PREDIcted M (PREDIM), was based on OGIS, BMI, 2 h glucose during OGTT and fasting insulin. Bland-Altman analysis revealed a good relationship between the M value and PREDIM in the validation dataset (only 9 of 154 observations out...Continue Reading

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Citations

Jul 12, 2020·Journal of Endocrinological Investigation·E Rebelos, M-J Honka
Jan 3, 2021·Acta Diabetologica·Daniel EppelChristian S Göbl
May 25, 2021·Journal of the Endocrine Society·Yanislava KarushevaJulia Szendroedi
Jun 30, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tianrong SongChunchun Chen
Jul 24, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Juying LiLin Luo
Jul 16, 2021·The Journal of Clinical Endocrinology and Metabolism·Desiree M SigalaKimber L Stanhope

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