Prediction of cognitive and motor outcome of preterm infants based on automatic quantitative descriptors from neonatal MR brain images

Scientific Reports
Pim MoeskopsManon J N L Benders

Abstract

This study investigates the predictive ability of automatic quantitative brain MRI descriptors for the identification of infants with low cognitive and/or motor outcome at 2-3 years chronological age. MR brain images of 173 patients were acquired at 30 weeks postmenstrual age (PMA) (n = 86) and 40 weeks PMA (n = 153) between 2008 and 2013. Eight tissue volumes and measures of cortical morphology were automatically computed. A support vector machine classifier was employed to identify infants who exhibit low cognitive and/or motor outcome (<85) at 2-3 years chronological age as assessed by the Bayley scales. Based on the images acquired at 30 weeks PMA, the automatic identification resulted in an area under the receiver operation characteristic curve (AUC) of 0.78 for low cognitive outcome, and an AUC of 0.80 for low motor outcome. Identification based on the change of the descriptors between 30 and 40 weeks PMA (n = 66) resulted in an AUC of 0.80 for low cognitive outcome and an AUC of 0.85 for low motor outcome. This study provides evidence of the feasibility of identification of preterm infants at risk of cognitive and motor impairments based on descriptors automatically computed from images acquired at 30 and 40 weeks PMA.

References

Jan 3, 2001·Brain : a Journal of Neurology·M AllinR M Murray
Aug 18, 2006·The New England Journal of Medicine·Lianne J WoodwardTerrie E Inder
Jul 16, 2011·PloS One·Beatrice LarroqueUNKNOWN Epipage Study group
Oct 15, 2011·AJNR. American Journal of Neuroradiology·B J M van KooijS J Counsell
Oct 15, 2011·Neurology·R RathboneA D Edwards
Jan 31, 2012·Developmental Medicine and Child Neurology·Jorrit F de KievietJaap Oosterlaan
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·K KeunenM J N L Benders
May 2, 2013·JAMA : the Journal of the American Medical Association·Fredrik SereniusUNKNOWN EXPRESS Group
Feb 18, 2014·The Journal of Pediatrics·Béatrice SkiöldUlrika Adén
Dec 10, 2014·Medical Image Analysis·Ivana IšgumMax A Viergever
Jan 3, 2015·Pediatrics·Susan R HintzUNKNOWN SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research
Apr 22, 2015·Pediatrics·Megan M Spencer-SmithPeter J Anderson
Aug 13, 2015·PloS One·Leonie J P SteenisAnneloes L van Baar
Sep 4, 2015·Brain : a Journal of Neurology·Henrik UllmanTorkel Klingberg
Mar 26, 2016·NeuroImage·Mohammad R ArbabshiraniVince D Calhoun
Apr 6, 2016·IEEE Transactions on Medical Imaging·Pim MoeskopsIvana Isgum
Dec 13, 2016·Pediatrics·Marine Bouyssi-KobarCatherine Limperopoulos

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Citations

May 19, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jessica DuboisManon J N L Benders
Sep 14, 2020·Pediatric Research·Claire E KellyPeter J Anderson
Jun 8, 2021·Frontiers in Pediatrics·Maria Luisa TatarannoManon J N L Benders
Jun 28, 2018·Pediatrics·Susan R HintzUNKNOWN SUPPORT study group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research

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Methods Mentioned

BETA
PMA

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