Prediction of cognitive decline by positron emission tomography of brain amyloid and tau.

Archives of Neurology
Gary W SmallJorge R Barrio

Abstract

To determine whether 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) brain regional values in individuals without dementia predict and correlate with future cognitive change. Two-year, longitudinal follow-up study. A university research institute. Volunteer sample of 43 middle-aged and older persons (median age, 64 years), including 21 with mild cognitive impairment (MCI) and 22 with normal aging. Longitudinal [(18)F]FDDNP positron emission tomography (PET) binding values in the medial and lateral temporal, posterior cingulate, parietal, frontal, and global (mean) regions of interest; neuropsychological test battery measuring 5 cognitive domains, including memory, language, attention (and information-processing speed), executive functioning, and visuospatial ability. For the entire study group (MCI and normal aging), increases in frontal, posterior cingulate, and global binding at follow-up correlated with progression of memory decline (r = -0.32 to -0.37, P = .03 to .01) after 2 years. Moreover, higher baseline [(18)F]FDDNP binding was associated with future decline in most cognitive domains, including language, attention, executive, and visuospatial abilities (r = -0...Continue Reading

Citations

Sep 2, 2014·Sports Health·Leah G ConcannonStanley A Herring
Nov 22, 2014·The Australian and New Zealand Journal of Psychiatry·Karra D HarringtonPaul Maruff
Jun 8, 2014·The American Journal of Sports Medicine·Shawn Love, Gary S Solomon
Nov 18, 2015·European Journal of Nuclear Medicine and Molecular Imaging·M DaniP Edison
Nov 2, 2013·Expert Review of Neurotherapeutics·Craig Gordon, Daniel J Martin
Jan 24, 2020·International Psychogeriatrics·Beatrix Krause-SorioHelen Lavretsky
Jul 7, 2012·Current Opinion in Neurology·Joseph C MasdeuKaren F Berman
Nov 11, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Peter J SnyderBrian Fernández
Feb 22, 2013·International Psychogeriatrics·Gary W SmallFernando Torres-Gil
Jan 18, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Anton ForsbergSamuel Svensson
Apr 8, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Timothy C DurazzoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 2, 2013·Brain : a Journal of Neurology·Yen Ying LimUNKNOWN AIBL Research Group
Jan 12, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yen Ying LimPeter J Snyder
Sep 17, 2014·The Journal of Nutrition, Health & Aging·P SaidlitzJ Delrieu
Mar 5, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yen Ying LimChristopher C Rowe
Feb 8, 2014·AJNR. American Journal of Neuroradiology·K Kantarci
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Jun WangJin-Tai Yu
Jul 25, 2018·Journal of Alzheimer's Disease : JAD·Stephen T ChenGary W Small
Jan 28, 2021·Seminars in Nuclear Medicine·Aren van WaardeRudi A J O Dierckx
Jul 17, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·David A MerrillGary W Small
Dec 17, 2017·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gary W SmallJorge R Barrio

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