Prediction of colorectal cancer relapse and survival via tissue RNA levels of matrix metalloproteinase-9

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Z S ZengJ G Guillem

Abstract

In this study, we investigated the association between matrix metalloproteinase (MMP)-9 RNA expression in primary colorectal cancer (CRC) and standard clinicopathologic variables and determined whether levels of MMP-9 RNA predict relapse and survival. Tumor and paired normal mucosa specimens from 71 primary CRC patients following resections were assessed. RNA levels were determined via Northern blot hybridization and quantitated with laser densitometry. Results were expressed as tumor/normal mucosa (T/N) fold-increase calculated after normalizing for RNA loading using 28S expression. Statistical analysis was performed using the SAS statistical package procedure. Kaplan-Meier survival curves were compared with the two-sided log-rank test. The mean T/N MMP-9 RNA fold-increase was 9.4 +/- 1.0 (mean +/- SE) (P < .001). Overexpression of MMP-9 RNA correlated significantly with status of synchronous distant metastases (M stage) (P = .004) and Dukes' stage (P = .008). A T/N fold-increase of 5.0 was used to discriminate between high (> 5.0) and low (< or = 5.0) T/N MMP-9 expression. High T/N MMP-9 RNA expression was associated with a significantly shorter disease-free (P = .0001) and overall (P = .0002) survival duration. In univariate...Continue Reading

Citations

Oct 12, 2000·Journal of Cellular Physiology·T TajirianC J Swallow
May 24, 2001·Annals of Surgery·M J HeslinM M Urist
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Naoto KamiyaHiroshi Ishikura
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Matthew G TuttonA Muti Abulafi
Sep 23, 2006·Clinical Chemistry·Jakob StenmanArto Orpana
Mar 19, 2008·Pathology Oncology Research : POR·László HerszényiZsolt Tulassay
Nov 19, 2009·Journal of Gastrointestinal Cancer·Abdelbaset BuhmeidaSeppo Pyrhönen
Dec 4, 2012·International Journal of Molecular Sciences·László HerszényiZsolt Tulassay
Jan 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong LiuHan Liang
Aug 23, 2018·Journal of Cellular Biochemistry·Somaye NoruziHamed Mirzaei
Oct 17, 2019·Journal of Clinical Medicine·Stavroula BaritakiCharalabos Pothoulakis
Jan 15, 1999·British Journal of Cancer·H L McLeod, G I Murray
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MichaelF A Shepherd
Jan 6, 2000·Molecular Pathology : MP·E A GarbettN J Brown
Jun 27, 2002·British Journal of Cancer·E T WaasT Hendriks
Oct 13, 2005·Cancer·Vasilis KaravasilisNicholas Pavlidis
May 19, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jose M Fernández-CebriánBeatriz Fernández-Escudero
Feb 18, 2014·Human & Experimental Toxicology·A K PanduranganS Ganapasam
Dec 12, 2012·BMC Clinical Pathology·Selja KoskensaloCaj Haglund
Apr 1, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland· Simpson Thompson
Jul 26, 2014·The American Journal of Dermatopathology·Tae Hyung KimMi Ryung Roh
Aug 26, 2014·BMC Cancer·Einas M YousefLouis A Gaboury
Nov 5, 1999·The Journal of Pathology·S Curran, G I Murray
Dec 4, 2003·The British Journal of Surgery·E T WaasT Hendriks
Oct 7, 2003·Annals of Surgical Oncology·William M BoedefeldMartin J Heslin
Sep 20, 2005·Breast Cancer Research : BCR·Kristina A Szabo, Gurmit Singh
Oct 20, 2010·International Journal of Cancer. Journal International Du Cancer·Dake ChuGang Ji
Jul 10, 2010·Annals of Surgical Oncology·Kouichirou TaharaMasaki Mori

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