Prediction of congenital hypothyroidism based on initial screening thyroid-stimulating-hormone

BMC Pediatrics
David S SalehPranesh Chakraborty

Abstract

In thyroid-stimulating-hormone (TSH)-based newborn congenital hypothyroidism (CH) screening programs, the optimal screening-TSH cutoff level is critical to ensuring that true cases of CH are not missed. Screening-TSH results can also be used to predict the likelihood of CH and guide appropriate clinical management. The purpose of this study is to evaluate the predictive value of various screening-TSH levels in predicting a diagnosis of CH in the Ontario Newborn Screening Program (ONSP). The initial screening and follow-up data of 444,744 full term infants born in Ontario, Canada from April 1, 2006 to March 31, 2010 were analyzed. Confirmed CH cases were based on local endocrinologists' report and initiation of thyroxine treatment. There were a total of 541 positive screening tests (~1/822 live births) of which 296 were true positives (~1:1,500 live births). Subjects were further subdivided based on screening-TSH and positive predictive values (PPV) were calculated. Twenty four percent in the 17-19.9 mIU/L range were true positives. In the 17-30 mIU/L range, 29 % were true positives with a significantly higher PPV for those sampled after (43 %) rather than before (25 %) 28 h of age (p < 0.02). Seventy three percent of neonates w...Continue Reading

References

Jan 1, 1996·The Journal of Clinical Endocrinology and Metabolism·J M DubuisG Van Vliet
Jan 1, 1997·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M Klett
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Judith SimpsonUNKNOWN Scottish Preterm Thyroid Group
Sep 8, 2005·The Journal of Clinical Endocrinology and Metabolism·Aidan McElduffBridget Wilcken
Dec 17, 2005·The Journal of Pediatrics·Jacoba J Bongers-Schokking, Sabine M P F de Muinck Keizer-Schrama
Oct 3, 2006·The Journal of Pediatrics·Vincent C SmithJoseph I Wolfsdorf
Jul 25, 2008·Thyroid : Official Journal of the American Thyroid Association·Robert BurnsPeter P A Smyth
Feb 5, 2009·The Journal of Clinical Endocrinology and Metabolism·Sophia D SakkaChristina Kanaka-Gantenbein
Aug 15, 2009·Archives of Disease in Childhood·Srinivasa Murthy KoradaTim Cheetham
Jul 8, 2010·Archives of Disease in Childhood·Heiko Krude, Oliver Blankenstein
Jul 31, 2012·The Journal of Pediatrics·Kara J ConnellyStephen H LaFranchi

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Citations

Aug 16, 2017·Thyroid : Official Journal of the American Thyroid Association·Allison M ButlerJoel Ehrenkranz
Feb 9, 2019·World Journal of Pediatrics : WJP·Alexander K C Leung, Alexander A C Leung
Dec 12, 2019·Autism Research : Official Journal of the International Society for Autism Research·Jennifer L AmesLisa A Croen
Jul 3, 2021·International Journal of Neonatal Screening·Altantuya TsevgeeErdenetuya Ganbaatar
Jan 9, 2020·Hormone Research in Pædiatrics·Reham S EbrhimRoy E Weiss
Nov 3, 2021·The Journal of Clinical Endocrinology and Metabolism·Alexa MarrSarah E Lawrence

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