Prediction of coronary artery disease by transesophageal echocardiographic detection of thoracic aortic plaque in patients with chronic kidney disease

Nephron. Clinical Practice
Yrjö LeskinenHeikki Saha

Abstract

Our aim was to examine the significance of thoracic aortic plaque detected by transesophageal echocardiography (TEE) in the prediction of coronary artery disease (CAD) in patients with chronic kidney disease (CKD). We examined 118 patients (mean age 52 +/- 12 years) with CKD and followed them for a mean of 3.4 +/- 0.8 years. The study group included 52 predialysis patients with moderate to severe CKD (plasma creatinine > or = 200 micromol/l), 32 patients on dialysis treatment, and 34 renal transplant recipients. At baseline, TEE was performed to evaluate thoracic aortic atherosclerosis. CAD was defined by a history of a documented myocardial infarction, a coronary angiogram or a post-mortem autopsy finding showing significant occlusive CAD by the end of the follow-up period. CAD was documented in 31 (26%) of the 118 study patients. The presence of thoracic aortic plaque had a sensitivity of 100% and a specificity of 37% for CAD and the positive and negative predictive values were 36 and 100%, respectively. In the subset of 36 patients with morphological findings of coronary arteries by angiogram or autopsy, the presence of large thoracic aortic plaques (> or = 3 mm in diameter) had a 73% sensitivity and 90% specificity for sign...Continue Reading

References

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Sep 18, 2001·Heart·A G Jardine, K McLaughlin
Aug 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yrjö LeskinenHeikki Saha
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yrjö LeskinenHeikki Saha

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Citations

May 22, 2010·The American Journal of Pathology·Kartik BalachandranAjit P Yoganathan
Jun 14, 2020·Wiener klinische Wochenschrift·Matthias SchneiderGeorg Goliasch

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