Prediction of coronary artery disease in patients undergoing operations for mitral valve degeneration

The Journal of Thoracic and Cardiovascular Surgery
S S LinM J Garcia

Abstract

We sought to develop and validate a model that estimates the risk of obstructive coronary artery disease in patients undergoing operations for mitral valve degeneration and to demonstrate its potential clinical utility. A total of 722 patients (67% men; age, 61 +/- 12 years) without a history of myocardial infarction, ischemic electrocardiographic changes, or angina who underwent routine coronary angiography before mitral valve prolapse operations between 1989 and 1996 were analyzed. A bootstrap-validated logistic regression model on the basis of clinical risk factors was developed to identify low-risk (< or =5%) patients. Obstructive coronary atherosclerosis was defined as 50% or more luminal narrowing in one or more major epicardial vessels, as determined by means of coronary angiography. One hundred thirty-nine (19%) patients had obstructive coronary atherosclerosis. Independent predictors of coronary artery disease include age, male sex, hypertension, diabetes mellitus,and hyperlipidemia. Two hundred twenty patients were designated as low risk according to the logistic model. Of these patients, only 3 (1.3%) had single-vessel disease, and none had multivessel disease. The model showed good discrimination, with an area under...Continue Reading

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Citations

Jun 7, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Shu-Chun LiZhi-Yun Xu
Sep 10, 2013·The Journal of Thoracic and Cardiovascular Surgery·Nassir M ThaljiHartzell V Schaff
Jun 9, 2005·The Journal of Thoracic and Cardiovascular Surgery·Eric LimNeil Moat

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