Prediction of creatinine clearance from serum creatinine

Nephron
D W Cockcroft, M H Gault

Abstract

A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

Associated Proceedings Papers

References

Jun 27, 2000·Journal of Clinical Ultrasound : JCU·C NicolauC Brú
Jun 1, 1996·Arthritis and Rheumatism·G PaseroO Della Casa-Alberighi
Feb 9, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·L GrubergL F Satler
Jan 17, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·L GrubergM B Leon
Oct 3, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Krishna J Rocha-SinghJaniece Rutherford
Nov 1, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Suhail AllaqabandTanvir K Bajwa
Jan 1, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·GianCarlo MarenziIvana Marana
Apr 4, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·L GrubergM B Leon
Jul 1, 1990·Journal of Clinical Pharmacology·L R ShikumaD E Zaske
Oct 1, 1990·Journal of Clinical Pharmacology·T L SchwinghammerE Gill
Feb 1, 1991·Journal of Clinical Pharmacology·D E ZaskeP R Kohls
Nov 1, 1992·Journal of Clinical Pharmacology·S Y ChuC Craft
Feb 1, 1992·Journal of Clinical Pharmacology·M Piquette-MillerF Jamali
Mar 1, 1992·Journal of Clinical Pharmacology·M G EllerR A Okerholm
May 1, 1993·Journal of Clinical Pharmacology·B R MeyersS Z Hirschman
Jun 1, 1993·Journal of Clinical Pharmacology·J M KovarikE Jähnchen
Jun 1, 1993·Journal of Clinical Pharmacology·B J ZarowitzH M Horst
Dec 1, 1994·Journal of Clinical Pharmacology·S C BoikeD K Jorkasky
Aug 1, 1995·Journal of Clinical Pharmacology·K M SowinskiD J Kazierad
Jan 1, 1995·Journal of Clinical Pharmacology·B L Carter
Jan 1, 1996·Journal of Clinical Pharmacology·T M GilmanS R Brunnemann
Feb 1, 1996·Journal of Clinical Pharmacology·J ShiP H Hinderling
Apr 1, 1996·Journal of Clinical Pharmacology·S L Preston, G L Drusano
Mar 20, 1998·Journal of Clinical Pharmacology·A A NomeirM N Cayen
Jun 1, 1997·Journal of Clinical Pharmacology·C E WrightG R Peters
May 23, 1998·Journal of Clinical Pharmacology·M BazungaJ Massarella

Related Concepts

Creatinine Clearance Measurement
Study, Methodological
Weighing Patient
Dicom Derivation
Kidney
Body Excretions
Teens
Excretory Function
Age Factors
Krebiozen

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.