PMID: 6112484May 23, 1981Paper

Prediction of death and major handicap in very preterm infants by brain ultrasound

Lancet
R J ThorburnK E Pape

Abstract

A linear-array real-time ultrasound scanner was used to examine the brains of all 95 infants born at less than 33 weeks of gestation who were admitted to the neonatal unit of University College Hospital in 1979. Abnormalities were detected in 41 (43%). 36 infants had haemorrhages into the germinal layer (GLH) and/or ventricles (IVH). 8 infants had cerebral atrophy (together with GLH/IVH in 5 infants). 8 (13%) of 63 infants with normal scans or small (grade-I) GLH/IVHs died, whereas 19 (59%) of 32 infants with larger haemorrhages or other intracranial lesions died (p less than 0.0005). At follow-up, at a median corrected age of 45 weeks, only 2 (4%) of 53 infants with normal scans or grade-I haemorrhages had evidence of major neurodevelopmental handicaps, but 5 (38%) of 13 infants with more extensive haemorrhages or cerebral atrophy had major handicaps (p less than 0.005). Brain scanning with ultrasound in the first days of life identified most infants in the population studied who subsequently died or survived with handicaps severe enough to be detected within the first year.

References

Jun 16, 1979·Lancet·K E PapeE O Reynolds
Feb 21, 1981·Lancet·A P LipscombM D Whitehead

❮ Previous
Next ❯

Citations

Sep 1, 1987·Indian Journal of Pediatrics·S Sinha, M Chiswick
Sep 23, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P JakobiS Blazer
Feb 1, 1984·Prostaglandins·L R MentC C Duncan
Jan 1, 1984·Clinical Radiology·M D CohenJ I Reider
Sep 1, 1984·The Journal of Pediatrics·L M DubowitzM I Levene
Aug 22, 1981·Lancet·R W CookeR F Massey
Jun 27, 1981·Lancet·M F JacobsonR H Syme
Feb 1, 1985·Australian Paediatric Journal·L J MurtonL C De Crespigny
Feb 1, 1987·Australian Paediatric Journal·R N PerryL de Crespigny
Apr 1, 1989·Australian Paediatric Journal·D I TudehopeG Williams
Jun 1, 1982·Archives of Disease in Childhood·M I LeveneR F Lamont
Jan 1, 1984·Archives of Disease in Childhood·R W Cooke, M E Morgan
Jul 1, 1984·Archives of Disease in Childhood·M I Levene, L de Vries
Jan 1, 1985·Archives of Disease in Childhood·A G Catto-SmithJ Astbury
Nov 1, 1986·Archives of Disease in Childhood·S W D'SouzaM L Chiswick
Nov 1, 1994·European Journal of Pediatrics·J U GrönlundI A Välimäki
Dec 1, 1991·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·F Guzzetta
Feb 1, 1987·Developmental Medicine and Child Neurology·A L StewartJ S Wyatt
Mar 1, 1990·Developmental Medicine and Child Neurology·D W BeverleyN Rhodes
Aug 1, 1988·Developmental Medicine and Child Neurology·P L HopeE O Reynolds
Dec 1, 1988·Developmental Medicine and Child Neurology·A M CostelloE O Reynolds
Jan 1, 1985·Journal of Perinatal Medicine·G D Shackelford, J J Volpe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.