Prediction of drug-drug interaction potential using physiologically based pharmacokinetic modeling

Archives of Pharmacal Research
Jee Sun Min, Soo Kyung Bae

Abstract

The occurrence of drug-drug interactions (DDIs) can significantly affect the safety of a patient, and thus assessing DDI risk is important. Recently, physiologically based pharmacokinetic (PBPK) modeling has been increasingly used to predict DDI potential. Here, we present a PBPK modeling concept and strategy. We also surveyed PBPK-related articles about the prediction of DDI potential in humans published up to October 10, 2017. We identified 107 articles, including 105 drugs that fit our criteria, with a gradual increase in the number of articles per year. Studies on antineoplastic and immunomodulatory drugs (26.7%) contributed the most to published PBPK models, followed by cardiovascular (20.0%) and anti-infective (17.1%) drugs. Models for specific products such as herbal products, therapeutic protein drugs, and antibody-drug conjugates were also described. Most PBPK models were used to simulate cytochrome P450 (CYP)-mediated DDIs (74 drugs, of which 85.1% were CYP3A4-mediated), whereas some focused on transporter-mediated DDIs (15 drugs) or a combination of CYP and transporter-mediated DDIs (16 drugs). Full PBPK, first-order absorption modules and Simcyp® software were predominantly used for modeling. Recently, DDI predictio...Continue Reading

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Citations

Sep 28, 2018·Annual Review of Pharmacology and Toxicology·J G Coen van Hasselt, Ravi Iyengar
Mar 21, 2019·Pharmacological Reviews·Gerard ClarkeNiall P Hyland
Nov 22, 2019·CPT: Pharmacometrics & Systems Pharmacology·Stephanie N LiuBrandon T Gufford
Oct 13, 2019·The Journal of Pharmacology and Experimental Therapeutics·Weize Huang, Nina Isoherranen
Jun 20, 2019·The AAPS Journal·Andrea TreyerPer Artursson
Dec 24, 2019·Acta Pharmaceutica Sinica. B·Yuhua LiHuichang Bi
Jan 19, 2021·The Oncologist·Nicolas ValletCatherine Poirot
Oct 29, 2020·Archives of Toxicology·Jukka HakkolaOlavi Pelkonen
Aug 20, 2021·Basic & Clinical Pharmacology & Toxicology·Aleksi TornioJanne T Backman
Nov 4, 2021·Expert Opinion on Drug Metabolism & Toxicology·Denise TürkThorsten Lehr

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